Patients who undergo autologous hematopoietic stem cell transplantation (aHCT) for treatment of a relapsed or refractory lymphoma are at risk of developing therapy related- myelodysplasia/acute myeloid leukemia (t-MDS/AML). Part of the risk likely resides in inherent interindividual differences in their DNA repair capacity (DRC), which is thought to influence the effect chemotherapeutic treatme...

Suboptimal cellular DNA repair capacity (DRC) has been shown to be associatedwith enhanced cancer risk, but genetic variants affecting the DRC phenotype have not been comprehensively investigated. In this study, with the available DRC phenotype data, we analyzed correlations between the DRC phenotype and genotypes detected by the Illumina 317K platform in 1,774 individuals of European ancestry ...

Although lung cancer is the paradigm of a tobacco-induced malignancy, host-specific factors modulate susceptibility to tobacco carcinogenesis. Variations in DNA repair may influence the rate of removal of DNA damage and of fixation of mutations. To test the hypothesis that genetically determined DNA repair capacity (DRC) modulates lung cancer susceptibility, we conducted a pilot case-control st...

In 2001, the Federal Emergency Management Agency (FEMA) required every Florida county to identify potential locations of disaster recovery centers (DRCs). The DRCs are to be opened and staffed by FEMA personnel, subsequent to any declared disaster. The Emergency Management Division of the Alachua County Department of Fire/Rescue Services sponsored a project to identify potential DRC sites. The ...

Cilia and flagella are highly conserved microtubule (MT)-based organelles with motile and sensory functions, and ciliary defects have been linked to several human diseases. The 9 + 2 structure of motile axonemes contains nine MT doublets interconnected by nexin links, which surround a central pair of singlet MTs. Motility is generated by the orchestrated activity of thousands of dynein motors, ...

Feedlot cattle performance data from 20 trials (n = 350 pen means; representing 3,365 steers) evaluating dietary inclusion of corn wet distillers grains plus solubles (WDGS) were summarized with two meta-analyses. The objective of this study was to evaluate the effects of WDGS inclusion level with dry-rolled corn (DRC) or a blend of DRC and high-moisture corn (HMC) for either calf-feds or yearl...

The Database of Ribosomal Cross-links (DRC) provides a complete collection of all the published data produced by cross-linking studies on the Escherichia coli ribosome, as well as on its components and functional ligands. The DRC currently includes data on 986 cross-links from >100 research papers, yielded by >40 different reagents. For each cross-link, information is given concerning its locat...