We removed single identified neurons from living Drosophila embryos to gain insight into the transcriptional control of developing neuronal networks. The microarray analysis of the transcriptome of two sibling neurons revealed seven differentially expressed transcripts between both neurons (threshold: log21.4). One transcript encodes the RNA splicing factor B52. Loss of B52 increases growth of ...

EXPERIMENT & RESULTS ・Augemntation of sports instruction using haptic system ・H(*5#16& 5*-& /'(:,;1& /9*C1'6& 0,2#& ;,'152,(-*9& ,-4('+*2,(-& intuitively&0#1-&2#1&/9*C1'6&*'1&(-&2#1&4,19; ・82,+B9*2,(-&B-,2&I8DJ&2(&=1&0('-&=C&2#1&/9*C1'&*-;&*-&,-62'B52,(-& B-,2&I3DJ&4('&2#1&,-62'B52(' ・"9*C1'6&'151,:1&;,'152,(-&,-62'B52,(-6&2#1C&6#(B9;&)(&,-7&=C&0*C& (4&:,='*2,(-6&)1-1'*21;&=C&13 vibration&*52B*...

Serine-/arginine-rich (SR) proteins are RNA-binding proteins that are primarily involved in alternative splicing. Expression of some SR proteins is frequently upregulated in tumors, and previous reports have demonstrated that these proteins can directly participate in cell transformation. Identifying factors that can rescue the effects of SR overexpression in vivo is, therefore, of potential th...

BACKGROUND The association of human leukocyte antigen (HLA) alleles and Takayasu arteritis (TA) is not fully understood. The aim of the present study was to investigate HLA alleles in Japanese patients with TA and the association of these alleles with clinical manifestations. METHODS AND RESULTS A total of 96 patients diagnosed with TA according to the Guideline for Management of Vasculitis S...

Regulation is widely considered as the key issue in reforms of public service sectors. But it has been pointed early to the problem that regulatory capture could undermine the stated aims of the reforms. This paper reviews the concept and the literature of regulatory capture under the special focus of public service sectors. Although mentioning corruption as an important mean way of capture, th...

This paper explores the evolution of a simple traffic convention concerning the side of the road on which to drive. This agent-based simulation probes some of the deeper conceptual issues involved in the evolution of conventions, particularly the nature of rational decision-making and its possible reliance upon habit. The simulations show that the systemic convergence to a left/right convention...

DNA- and RNA-processing pathways are integrated and interconnected in the eukaryotic nucleus to allow efficient gene expression and to maintain genomic stability. The recruitment of DNA Topoisomerase I (Topo I), an enzyme controlling DNA supercoiling and acting as a specific kinase for the SR-protein family of splicing factors, to highly transcribed loci represents a mechanism by which transcri...

Schaffer [Schaffer, M.E., 1988. Evolutionarily stable strategies for a finite population and a variable contest size. Journal of Theoretical Biololgy 132, 469–478] proposed a concept of evolutionary stability for finite-population models that has interesting implications in economic models of evolutionary learning, since it is related to perfectly competitive equilibrium. The present paper expl...

Deciphering the role of alternative splicing in developmental processes relies on the identification of key genes whose expression is controlled by splicing regulators throughout the growth of a whole organism. Modulating the expression levels of five SR proteins in the developing eye of Drosophila melanogaster revealed that these splicing factors induce various phenotypic alterations in eye or...

The relevant competitors in regard to innovation might, but not necessarily do, correspond to the identified competitors on actual product markets. Hence, the conventional analysis of product markets, in order to assess the potential anticompetitive effects of mergers, is insufficient to capture innovation competition in its full extent. As a consequence, the aim of this article is to introduce...