In this research work, the original 45S5 bioactive glass was modified by introducing zinc and/or strontium oxide (6 mol%) in place of calcium oxide. Sr was added for its ability to stimulate bone formation and Zn for its role in bone metabolism, antibacterial properties, and anti-inflammatory effect. The glasses were produced by means of melting and quenching process. SEM and XRD analyses evide...

The present work investigates, in situ, the in vitro bioactivity of partially crystallized 45S5 Bioglass (BG) as a function of immersion time in a simulated body fluid (SBF) using atomic force microscopy (AFM). The results obtained for the crystallized BG were compared to those of hydroxyapatite c- and a-faces. The calcium phosphate layer grows on the crystallized 45S5 B by multiple two-dimensi...

The aim of this study was to investigate the histological and histomorphometrical bone response to three Biosilicates with different crystal phases comparing them to Bioglass 45S5 implants used as control. Ceramic glass Biosilicate and Bioglass 45S5 implants were bilaterally inserted in rabbit femurs and harvested after 8 and 12 weeks. Histological examination did not revealed persistent inflam...

INTRODUCTION: Osteoporotic patients, smokers and diabetics are among those who represent higher risks with regard to bone formation. In these clinical situations where bone regeneration can be especially difficult there is a need for an active agent or material which can stimulate osteoblasts in addition to providing a scaffold for growth. Extensive research has been performed on silicon and ca...

-The bioactive glass 45S5 (Hench glass), having composition 45 SiO2 24.5 Na2O 24.5 CaO -6 P2O5 (wt %) were prepared with substituted Li2O, K2O, ZnO, MgO, and B2O3 by conventional melting process in an electric globar furnace at 1400±10 OC. The Controlled crystallization were carried out to convert the bioglasses to their corresponding bioglass ceramics. Nucleation and crystallization regimes we...