Hypoxia-inducible factors (HIF) are essential transcriptional regulators that mediate adaptation to hypoxic stress in rapidly growing tissues such as tumors. HIF activity is regulated by hypoxic stabilization of the related HIF-1A and HIF-2A subunits, which are frequently overexpressed in cancer cells. To assess the relative tumor-promoting functions of HIF-1A and HIF-2A directly, we replaced H...

Zou, Ai-Ping, Zhi-Zhang Yang, Pin-Lan Li, and Allen W. Cowley, Jr. Oxygen-dependent expression of hypoxiainducible factor-1a in renal medullary cells of rats. Physiol Genomics 6: 159–168, 2001.—Hypoxia-inducible factor-1a (HIF-1a) is a transcription factor that regulates the oxygendependent expression of a number of genes. This transcription factor may contribute to the abundant expression of m...

OBJECTIVES Hypoxia-inducible factor-1alpha (HIF-1a) is widely considered to be one of the key regulators in cancer cells. Here, we investigated a microRNA regulating expression of HIF-1a and explored its functions in clear cell renal cell carcinoma (ccRCC) cells. METHODS AND MATERIALS Western blot and reporter assays were used to assess HIF-1a as a direct target of miR-138. The effects of miR...

OBJECTIVE Hypoxia-inducible factor (HIF) is considered an important transcription factor due to its roles in glycolysis, angiogenesis, cell differentiation, apoptosis, and other cellular pathways. It takes the role in various physiological and pathological states, such as solid tumors, vascular injury, and atherosclerotic lesion progression. In recent studies, HIF is found as a master regulator...

The transcription factor hypoxia-inducible factor (HIF)-1 is an important mediator of hypoxic adaptation of tumor cells and controls several genes that have been implicated in tumor growth. Oxygen-dependent degradation of HIF-1a, the regulatory subunit, requires binding to the von Hippel Lindau (VHL) protein. Because functional inactivation of the VHL tumor suppressor gene occurs in up to 70% o...

The transcription factor hypoxia-inducible factor (HIF)-1 is an important mediator of hypoxic adaptation of tumor cells and controls several genes that have been implicated in tumor growth. Oxygen-dependent degradation of HIF-1a, the regulatory subunit, requires binding to the von Hippel Lindau (VHL) protein. Because functional inactivation of the VHL tumor suppressor gene occurs in up to 70% o...

Enzalutamide is a potent second-generation androgen receptor (AR) antagonist with activity in metastatic castrate-resistant prostate cancer (CRPC). Although enzalutamide is initially effective, disease progression inevitably ensues with the emergence of resistance. Intratumoral hypoxia is also associated with CRPC progression and treatment resistance. Given that both AR and hypoxia inducible fa...

Chávez, Juan C., Faton Agani, Paola Pichiule, and Joseph C. LaManna. Expression of hypoxia-inducible factor-1a in the brain of rats during chronic hypoxia. J Appl Physiol 89: 1937–1942, 2000.—Hypoxia-inducible factor-1 (HIF-1) is a transcription factor that regulates adaptive responses to the lack of oxygen in mammalian cells. HIF-1 consists of two proteins, HIF-1a and HIF-1b. HIF-1a accumulate...

Neovascularization and increased glycolysis, two universal characteristics of solid tumors, represent adaptations to a hypoxic microenvironment that are correlated with tumor invasion, metastasis, and lethality. Hypoxia-inducible factor 1 (HIF-1) activates transcription of genes encoding glucose transporters, glycolytic enzymes, and vascular endothelial growth factor. HIF-1 transcriptional acti...

Hypoxia-inducible factor-1A (HIF-1A) is overexpressed in many human tumors and their metastases, and is closely associated with a more aggressive tumor phenotype. In this study, we investigated the effect of resveratrol, a natural product commonly found in grapes and various other fruits, on hypoxia-induced HIF-1A protein accumulation and vascular endothelial growth factor (VEGF) expression in ...