PURPOSE To investigate whether the application of a particular platelet-rich plasma preparation rich in growth factors (PRGF) during anterior cruciate ligament (ACL) surgery gives a potential advantage for better tendon graft ligamentization. METHODS This study included 37 volunteers who underwent either conventional (control group, n = 15) or PRGF-assisted (n = 22) ACL reconstruction with an...

Introduction Platelet-rich-plasma (PRP) is autologous plasma that has a platelet concentration above baseline. Upon activation, PRP releases a high concentration of various growth factors. Platelet -released growth factors (PRGF) have been used to support the repair of bone defects, especially in maxillofacial and dental surgery, yet their exact effect on bone healing is not clear. We previousl...

Abstract Study question Does the use of platelet growth factors instilled into thin endometrium in oestrogen-replacement treatment cycles improve endometrial thickness? Summary answer The improves What is known already Thin impairs implantation rates and IVF outcomes. To date there no effective to proliferation. PRGF-Endoret used multiple clinical indications. autologous collection (PRGF), appl...

OBJECTIVE To evaluate the efficacy of topically applied autologous plasma rich in growth factors (PRGF) as a treatment for persistent epithelial defects (PEDs) of the cornea. METHODS A series of prospective noncomparative cases. PARTICIPANTS Twenty eyes from 18 patients with PED with various underlying etiopathologies: neurogenic, iatrogenic, associated with burning or secondary to severe d...

OBJECTIVE To obtain preliminary information about the effectiveness of intra-articular injections of an autologous preparation rich in growth factors (PRGF) for knee OA treatment to be explored further in future studies. METHODS We have characterized PRGF treatment by platelet count and concentration of relevant growth factors (TGF-Beta1, PDGF-AB, VEGF-A; HGF and IGF-I) involved in healing me...

PURPOSE The aim of this study was to evaluate the clinical efficiency of the subepithelial connective tissue graft (SCTG) with and without plasma rich in growth factor (PRGF) in the treatment of gingival recessions. METHODS Twenty bilateral buccal gingival Miller's Class I and II recessions were selected. Ten of the recessions were treated with SCTG and PRGF (test group). The rest ten of the ...

BACKGROUND Plasma rich in growth factors (PRGF) and freeze-dried bone allograft (FDBA) are shown to promote bone healing. This study was aimed to histologically and histomorphometrically investigate the effect of combined use of PRGF and FDBA on bone formation, and compare it to FDBA alone and control group. MATERIALS AND METHODS The distal roots of the lower premolars were extracted bilatera...

OBJECTIVES Preparations rich in growth factors (PRGF) release them plus bioactive proteins at localized sites, with the aim of triggering healing and regenerative processes. The prevailing paradigm suggests that their influence on proliferation, angiogenesis and the extracellular matrix synthesis is minimal. However, variations in their composition and impact on different cell phenotypes have n...

BACKGROUND Platelet-rich fibrin matrices release a natural mixture of growth factors that play central roles in the complex processes of tendon healing. HYPOTHESIS Application of autologous platelet-rich matrices during Achilles tendon surgery may promote healing and functional recovery. STUDY DESIGN Case-control study and descriptive laboratory study; Level of evidence, 3. METHODS Twelve...

Background The treatment of furcation area defects remained as a challenging issue in periodontal treatments. Regeneration treatment of furcation defects is the most discussed periodontal treatment. Although not completely hopeless in prognosis, the presence of the furcation involvement significantly increases the chance of tooth loss. The current research was conductedeto compare theeadditive ...