2010.6 The National Institute on Alcoholism and Alcohol Abuse (NIAAA) formed a special task force to make recommendations to address the problem.7 Binge drinking has even received global attention from the World Health Organization, which convened a conference to address the topic.8 Several prominent organizations and key leaders have accepted this call to action. Mothers Against Drunk Driving ...

Since survival time is a quantitative variable, why can’t we just use the usual techniques from Table I? Before we explain the main reason why we use survival analysis, let’ us consider a simple example on the survival times (in months) for 25 lung cancer patients who all died; the timings are : 1, 5, 6, 6, 9, 10, 10, 10, 12, 12, 12, 12, 12, 13, 15, 16, 20, 24, 24, 27, 32, 34, 36, 36, 44 months...

BACKGROUND/AIMS Increasing evidence has shown that miR-203 plays important role in human cancer progression. However, little is known about the function of miR-203 in osteosarcoma (OS). METHODS The expression of miR-203 in OS tissues and cell lines were examined by qRT-PCR. The biological role of miR-20 in OS cell proliferation was examined in vitro and in vivo. The targets of miR-203 were id...

2-(4-Amino-3-methylphenyl)benzothiazole (DF 203, NSC 674495) is a candidate antitumor agent with potent and selective activity against human-derived tumor cell lines in vitro and in vivo. Only sensitive cell lines (e.g., MCF-7) were able to accumulate and metabolize DF 203, forming the main inactive metabolite, 2-(4-amino-3-methylphenyl)-6-hydroxybenzothiazole (6-OH 203). Selective metabolism m...

The present study investigated the relationship between microRNA-203 (miR-203) and the p53 upregulated modulator of apoptosis (Puma) in colon (HCT116) and lung cancer (A549) cells. Colon and lung cancer cell lines were selected for this study since a relationship between p53/miR-203 and p53/Puma has been established in both cancers. In the present study, adriamycin and nutlin-3 were used to act...

BACKGROUND/AIMS MicroRNA (miRNA) plays important roles in the development of different cancers. In this study, we investigated the roles and mechanisms of miR-203 in human cervical cancer. METHODS miR-203 expression was detected in cervical cancer tumors and cell lines by qRT-PCR. The methylation status in the promoter region of miR-203 was examined by methylation-specific PCR. The functional...

In lab-scale experiments at the 2-stage activated sludge pilot plant of Vienna’s central WWTP it is shown that the wastewater soluble COD concentration, which is inert to a sludge with SRT < 1 d (SIA) is about double compared to the SI concentration in sludge with SRT > 10 d (SIB). Unexpectedly the ratio of SIA/SIB is independent of the sludge age between SRTs of 0.4 and 1.0 days. The differenc...