نتایج جستجو برای: ماده 221 قم
تعداد نتایج: 46368 فیلتر نتایج به سال:
Increasing evidence has demonstrated that microRNAs (miRNAs or miRs) are involved in cancer initiation and progression. Previous studies have indicated that miR-221 is one of the most consistently overexpressed miRNAs in multiple types of cancer. However, the role of miR-221 in osteosarcoma carcinogenesis and progression is not yet fully understood. Thus, the aim of the present study was to exa...
UNLABELLED Deregulated cell proliferation and apoptosis play a major role in hepatocellular carcinoma (HCC). MicroRNAs participate in the modulation of key molecules linked to hepatocarcinogenesis. PURPOSE This study aims to investigate the role of miR-221 in the modulation of Bmf, a proapoptotic BH3-only protein, and to characterize miR-221 contribution to hepatocarcinogenesis through modula...
BACKGROUND & AIM The miR-221/222 cluster is upregulated in malignant plasma cells from multiple myeloma (MM) patients harboring the t(4;14) translocation. We previously reported that silencing of miR-221/222 by an antisense oligonucleotide induces anti-MM activity and upregulates canonical miR-221/222 targets. The in vivo anti-tumor activity occurred when miR-221/222 inhibitors were delivered d...
1 The Florey Institute of Neuroscience and Mental Health, Parkville, Victoria, Australia 2 CogState Ltd., Melbourne, Victoria, Australia 3 Department of Psychiatry, Yale University School of Medicine, New Haven, CT, USA 4 Academic Unit for Psychiatry of Old Age, St. Vincent’s Health, Department of Psychiatry, The University of Melbourne, Kew, Victoria, Australia 5 National Ageing Research Insti...
may be many years in the past. The accuracy of reporting on sensitive matters relating to sexual behavior can also shift as the culture changes, and that accuracy may vary with age. Because, by definition, self-reports of the initiation of sexual activity cannot be externally validated, the scientific literature has necessarily focused on the consistency and reliability of reporting, through tw...
Giriş: Obstrüktif uyku apne sendromu (OUAS) ve bronş hiperreaktivitesi (BHR) arasındaki ilişki iyi bilinmemektedir. Bu çalışmada, OUAS’lı hastalarda hastalığın şiddeti ve BHR arasındaki ilişkiyi araştırdık. Materyal ve Metod: Bu çalışmaya polisomnografileriyle OUAS tanısı alan 47 (37’si erkek, 10’u kadın) hasta alındı. Histamin provokasyon testi yapıldı ve beden kitle indeksi (BKİ, kg/m2) hesap...
ماده 221 قانون مدنی ایران در مورد جبران خسارات حاصل از عدم اجرای تعهّدات قراردادی و شرایط آن، هم از این جهت که سابقه فقهی روشنی ندارد و هم از جهت عدم انطباق با نظایر خارجی خود، ماهیّت روشنی ندارد. به همین علّت، آن چه که در نوشته های حقوقی آمده است نیز یکسان و یکنواخت نیستند؛ برخی آن را ناشی از سکوت فقه در خصوص مسئولیّت قراردادی دانسته، و گروهی دیگر، دلیل وضع آن را پوشش دادن به نقص ابزارهای فقهی ناظ...
Increasing evidence suggests that lineage specific subpopulations and stem-like cells exist in normal and malignant breast tissues. Epigenetic mechanisms maintaining this hierarchical homeostasis remain to be investigated. In this study, we found the level of microRNA221 (miR-221) was higher in stem-like and myoepithelial cells than in luminal cells isolated from normal and malignant breast tis...
MiR-221 Exacerbate Cell Proliferation and Invasion by Targeting TIMP3 in Papillary Thyroid Carcinoma
MiR-221 is frequently upregulated in papillary thyroid cancer (PTC) tissues and cell lines, and this study was designed to validate the association of miR-221 with PTC proliferation, apoptosis, and migration. We observed that miR-221 suppressed TIMP3 expression by binding to 3' untranslated region of TIMP3 mRNA, and TIMP3 expression was increased with the presence of miR-221 inhibitors; TIMP3 s...
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