Weaning pigs (7.9 +/- 1.7 kg) were fed a freeze-dried powder of marionberry (MB) by stomach tube to study the absorption and metabolism of anthocyanins. Four major anthocyanins (ACNs) were found in MB: cyanidin-3-glucoside (Cy-3-glc, 78%), cyanidin-3-rutinoside (Cy-3-rutin, 20%), pelargonidin-3-glucoside (Pg-3-glc, 0.4%), and 1 unknown acylated cyanidin-based ACN (UACy, 1.5%). In the urine, the...

Preclinical studies of resistance to alkylating agents in the Lewis x Brown Norway hybrid (LBN) rat model of acute myeloid leukemia (AML) have hitherto been limited by the sensitivity of LBN AML cells to cyclophosphamide (CY). We developed a CY-resistant subline of LBN AML by serial intravenous (IV) passage of AML cells followed by in vivo exposure to CY (100 mg/kg) 14 days later. After 18 and ...

BACKGROUND The prognosis for patients with scirrhous gastric cancer (SGC) is extremely poor. However, the management protocol for this type of cancer has not been well discussed. In this study, we retrospectively evaluated the management of SGC and we introduced a new treatment protocol for SGC. PATIENTS AND METHODS Between 1991 and 2001, 58 patients with SGC were treated. Thirty-nine, who un...

Peripheral blood progenitor cell mobilization with intermediate-dose cyclophosphamide (ID-CY) and granulocyte colony-stimulating factor (G-CSF) has been shown to be more efficacious, albeit more toxic, than low-dose cyclophosphamide (LD-CY) mobilization regimens in patients with multiple myeloma treated with conventional therapies. However, the relative importance of cyclophosphamide dose inten...

The choice of conditioning regimen before allogeneic stem cell transplantation (SCT) in patients with acute lymphoblastic leukemia (ALL) is important. We retrospectively compared outcomes of medium-dose VP-16/cyclophosphamide/total body irradiation (VP/CY/TBI) regimen and CY/TBI. Five hundred and twenty-nine patients (VP/CY/TBI: n = 35, CY/TBI: n = 494) who met all of the following criteria wer...

In the early 1990s, 4 randomized studies compared conditioning regimens before transplantation for leukemia with either cyclophosphamide (CY) and total-body irradiation (TBI), or busulfan (Bu) and CY. This study analyzed the long-term outcomes for 316 patients with chronic myeloid leukemia (CML) and 172 patients with acute myeloid leukemia (AML) who participated in these 4 trials, now with a me...

We have demonstrated that hydrocortisone (HC) enhances the antitumor action of cyclophosphamide (CY). When sar coma-bearing C57BL/6J, BALB/cByJ, and C3H/HeJ mice were given a single injection i.p. of CY (300 mg/kg), followed 1 to 3 days later by a s.c. injection of HC (10 mg in 0.1 ml of incomplete Freund's adjuvant), there was a dramatic acceler ation of the reduction in tumor size compared wi...

This study is aimed at screening non-Saccharomyces for amino acids decarboxylation potentials. The yeasts were isolated from banana fruit and honey purchased markets in Rivers State. isolation molecular identification of yeast isolates according to standard microbiological procedures. A plate assay method acid (biogenic amine production) was used. Wild Non-Saccharomyces (NSY) identified as Cand...

Background:This study aimed to investigate changes in calcitonin cells (C cells) and parathyroid glands (PTG) induced by cypermethrin exposure in rats and evaluate the protective effects of jamun seeds (Syzygium cumini; JSE) and orange peels (Citrus sinensis; OPE) extracts. Methods:Wistar rats (N=120) were treated in groups of 20 each as: Group A: Controls; Group B: cypermethrin (CY); Group C:...