The host range of the B-lymphotropic papovavirus (LPV) in cultured human cells is limited to a few B-lymphoma-derived cell lines. The constitutively expressed cell surface receptor for the virus is a major determinant restricting the LPV host range (G. Haun, O. T. Keppler, C. T. Bock, M. Herrmann, H. Zentgraf, and M. Pawlita, J. Virol. 67:7482-7492, 1993). Here we show that human B-lymphoma cel...

Three different schemes for Fault Tolerant Control (FTC) based on Adaptive Control in combination with Artificial Neural Networks (ANN), Robust Control and Linear Parameter Varying (LPV) systems are compared. These schemes include a Model Reference Adaptive Controller (MRAC), a MRAC with an ANN and a MRAC with an H∞ Loop Shaping Controller for 4 operating points of an LPV system (MRAC-4OP-LPV, ...

In this paper a novel method is proposed for constructing linear parameter varying (LPV) system models through adaptation. For a class of nonlinear systems, an LPV model is built using its linear part, and its coefficients are considered as time-varying parameters. The variation in time is controlled by an adaptation scheme with the goal of keeping the trajectories of the LPV system close to th...

OBJECTIVE The neurotoxic actions of the HIV protease inhibitors, amprenavir (APV) and lopinavir (LPV) were investigated. DESIGN With combination antiretroviral therapy (cART), HIV-infected persons exhibit neurocognitive impairments, raising the possibility that cART might exert adverse central nervous system (CNS) effects. We examined the effects of LPV and APV using in-vitro and in-vivo assa...

In adult protease inhibitor (PI)-experienced patients, a lopinavir (LPV) phenotypic inhibitory quotient (PIQ) of >15 has been associated with a higher likelihood of viral suppression. The aims of this study were to develop a population pharmacokinetic (PK) model of LPV in children and to estimate the probability of achieving a PIQ of >15. HIV-infected, PI-experienced children receiving LPV were...

introduction: the use of lopinavir/ritonavir (lpv/r) has decreased morbidity and mortality due to human immunodeficiency virus (hiv); however its use could be impaired by hepatotoxicity. therefore, this study was designed to investigate the effects of melatonin (mt) and alpha lipoic acid (ala) on lpv/r-induced hepatotoxicity in male albino rats. methods: rats were divided into groups and treate...

This paper is concerned with the reduction of the number of parameters of LPV and quasi LPV models for the synthesis of LPV gain scheduling controllers. The number of parameters is reduced by the principal component analysis of typical scheduling trajectories. This method enables a systematic trade-off between the number of reduced parameters and the desired accuracy. The approach is illustrate...

Background. We aimed to assess cardiac conduction safety of coadministration of the CYP3A4 inhibitor lopinavir/ritonavir (LPV/r) and the CYP3A4 substrate artemether-lumefantrine (AL) in HIV-positive Ugandans. Methods. Open-label safety study of HIV-positive adults administered single-dose AL (80/400 mg) alone or with LPV/r (400/100 mg). Cardiac function was monitored using continuous electrocar...

This work studies the identification and control of circulation fluidized bed (CFB) boilers. The CFB boiler under investigation shows strong nonlinearity due to big changes of steam load. A linear parameter varying (LPV) model is used to represent the process dynamics and used in control. The steam flow is used as the working-point variable (scheduling variable) of LPV model. Multivariable plan...

OBJECTIVES To compare the efficacy and safety of an individualized treatment-simplification strategy consisting of switching from a highly-active anti-retroviral treatment (HAART) with a ritonavir-boosted protease inhibitor (PI/r) and 2 nucleoside reverse-transcriptase inhibitors (NRTIs) to lopinavir/ritonavir (LPV/r) monotherapy, with intensification by 2 NRTIs if necessary, to that of continu...