BACKGROUND Worsening renal function (WRF) in the setting of heart failure has been associated with increased mortality. However, it is unclear if this decreased survival is a direct result of the reduction in glomerular filtration rate (GFR) or if the mechanism underlying the deterioration in GFR is driving prognosis. Given that WRF in the setting of angiotensin-converting enzyme inhibitor (ACE...

BACKGROUND Renin-angiotensin aldosterone system (RAAS) inhibitors significantly improve outcome in heart failure (HF) patients with reduced ejection fraction (HFREF), irrespective of the occurrence of worsening renal function (WRF). However, in HF patients with preserved ejection fraction (HFPEF), RAAS inhibitors have not been shown to improve outcome but are still frequently prescribed. METH...

We aimed to establish the prevalence and effect of worsening renal function (WRF) on survival among patients with acute decompensated heart failure. Furthermore, we sought to establish a risk score for the prediction of WRF and externally validate the previously established Forman risk score. A total of 657 consecutive patients with acute decompensated heart failure presenting to the emergency ...

OBJECTIVE The objective of the study was to assess urinary biomarkers of renal injury for their individual or collective ability to predict Worsening renal function (WRF) in patients with acutely decompensated heart failure (ADHF). METHODS In a prospective, blinded international study, 87 emergency department (ED) patients with ADHF were evaluated with biomarkers of cardiac stretch (B type na...

The Weather Research and Forecast (WRF) model was run over South-east Australia from 1985 through 2008. The model used the following physics schemes: WRF Single Moment 5-class microphysics scheme; Rapid Radiative Transfer Model longwave radiation scheme; Dudhia shortwave radiation scheme; Monin-Obukhov surface layer similarity; Noah land-surface scheme; Yonsei University boundary layer scheme a...

This discussion paper is/has been under review for the journal Geoscientific Model Development (GMD). Please refer to the corresponding final paper in GMD if available. Abstract We describe the physical model, numerical algorithms, and software structure of WRF-Fire. WRF-Fire consists of a fire-spread model, implemented by the level-set method, coupled with the Weather Research and Forecasting ...