Little is known about genetic mechanisms that regulate the ratio of cortical excitatory and inhibitory neurons. We show that NPAS1 and NPAS3 transcription factors (TFs) are expressed in progenitor domains of the mouse basal ganglia (subpallium, MGE, and CGE). NPAS1(-/-) mutants had increased proliferation, ERK signaling, and expression of Arx in the MGE and CGE. NPAS1(-/-) mutants also had incr...

This paper carries out a survey of CGE and Microsimulation models used in the evaluation of issues related directly or indirectly to incomes distribution. Different model structures are discussed which have been employed for country-specific, multi-country and region-specific studies. The paper considers the relevance of a relatively recent approach in modeling_linking CGE frameworks with micro...

This chapter is an introduction to the subject of computable general equilibrium (CGE) modeling in environmental and resource economics. CGE models are a widely-used tool for the quasi-empirical analysis of environmental externalities—and policies for mitigating them—which are large enough to influence prices across multiple markets in the economy. We provide a simple, rigorous, and practically...

Traditional computable general equilibrium (CGE) models based on the Armington assumption fail to capture the extensive margin of trade, and thereby underestimate the trade and welfare effects of trade opening. To address this problem, this paper introduces the Melitz (2003) theoretical framework with firm heterogeneity and fixed exporting costs into a global CGE model. Some illustrative simula...

The maturation of inhibitory GABAergic cortical circuits regulates experience-dependent plasticity. We recently showed that the heterochronic transplantation of parvalbumin (PV) or somatostatin (SST) interneurons from the medial ganglionic eminence (MGE) reactivates ocular dominance plasticity (ODP) in the postnatal mouse visual cortex. Might other types of interneurons similarly induce cortica...

A CGE method for monitoring the disulfide isomer distribution characteristic of IgG2 MAbs is presented. Disulfide heterogeneity of MAbs has been studied using various chromatographic and electrophoretic methods. Although CGE operates using a different selectivity mechanism from that of sorption chromatographic techniques, similar trends are present in the data, which allow the CGE method to be ...

Traditional computable general equilibrium (CGE) models have ignored uncertainty ─ even when applied to fields such as environmental modeling that are replete with economic uncertainty. In contrast, many control theory models have focused on the effects of uncertainty. Thus marrying the tradition of CGE and control modeling can result in pricequantity models with explicit dynamics and careful t...

BACKGROUND Bisphenol-A (BPA) is one of the widespread industrial compounds, which has adverse effects on animal and human health. The study was aimed to explore the effects of Crassostrea gigas extracts (CGE) in alleviating ovarian functional disorders of female rats with exposure to BPA and the underlying possible mechanism. MATERIALS AND METHODS Eighteen four-week-old female Sprague-Dawley ...

Computable general equilibrium (CGE) models are ubiquitous in energy and environmental economics research. Recent technological advancements in electricity fuels, generation technologies, and environmental policies which target specific generation technologies (e.g., emission regulations) have motivated detailed CGE modeling of the electricity sector. Modeling these issues requires distinct ele...