The pathophysiology of sepsis involves complex cytokine and inflammatory mediator networks, a mechanism to which NF-κB activation is central. Downregulation of endothelial nitric oxide synthase (eNOS) contributes to sepsis-induced endothelial dysfunction. Erythropoietin (EPO) has emerged as a major tissue-protective cytokine in the setting of stress. We investigated the role of EPO in sepsis-re...

This paper presents a novel approach, using hybrid feature selection (HFS), machine learning (ML), and particle swarm optimization (PSO) to predict optimize construction labor productivity (CLP). HFS selects factors that are most predictive of CLP reduce the complexity data. Selected used as inputs for four ML models prediction. The study results showed random forest (RF) obtains better perform...

Constraint Logic Programming (CLP) is a relatively new programming paradigm. During its ten years of existence, the theory of CLP has been increasingly understood and the two diierent approaches, domain technology and incremental linear solving, have been implemented in various CLP systems. Meanwhile, the commercial attractivity of CLP has been growing. Since 1989 a couple of commercial CLP sys...

The activity of 5-LO (5-lipoxygenase), which catalyses two initial steps in the biosynthesis of pro-inflammatory LTs (leukotrienes), is strictly regulated. One recently discovered factor, CLP (coactosin-like protein), binds 5-LO and promotes LT formation. In the present paper we report that CLP also stabilizes 5-LO and prevents non-turnover inactivation of the enzyme in vitro. Mutagenesis of tr...

Collagen is an abundant, triple-helical protein comprising three strands of the repeating sequence: Xaa-Yaa-Gly. (2S)-Proline and (2S,4R)-4-hydroxyproline (Hyp) are common in the primary structure of collagen. Here, we use nonnatural proline derivatives to reveal determinants of collagen stability. Specifically, we report high-yielding syntheses of (2S,4S)-4-chloroproline (clp) and (2S,4R)-4-ch...

Citrulline (Cit) supplementation was proposed to serve as a therapeutic intervention to restore arginine (Arg) concentrations and improve related functions in sepsis. This study explored whether citrulline had positive effects on liver injury and cytokine release in the early stages of sepsis. The cecal ligation and puncture (CLP) model was utilized in our study. Rats were divided into four gro...

BACKGROUND Administration of a selective β1-blocker, such as esmolol, in human septic shock has demonstrated cardiovascular protective effects related to heart rate reduction. Certain experimental data also indicate that esmolol exerts systemic anti-inflammatory and beneficial effects on vascular tone. Thus, the present study aimed to determine whether a non-chronotropic dose of esmolol maintai...

Sepsis causes mitochondrial oxidative injury and swelling. Ethyl pyruvate (EP) is a cytoprotective agent, while aquaporin-8 (AQP8) is a mitochondrial water channel that can induce mitochondrial swelling. We assessed whether EP protects mitochondria during sepsis, and whether AQP8 contributes to the underlying mechanisms. A cecal ligation and puncture (CLP) sepsis model was established in Spragu...

Taurodontism and root dilaceration are developmental anomalies. Both taurodontism might be related with cleft lip palate (CLP). This study aimed to investigate the prevalence of dilaceration, in children CLP. Cone beam computed tomography images 200 (100 100 healthy) CLP were evaluated retrospectively. level was divided into three subtypes as hypertaurodont, mesotaurodont hypotaurodont. Root re...