To deliver and retain viable repair cells in a surgically prepared cartilage lesion, we previously developed an adhesive in situ-gelling cell carrier by suspending cells in a solution of hydroxyethyl cellulose (HEC), which was then mixed with chitosan-glycerol phosphate to form a chitosan-GP/HEC gel. The purpose of this study was to elucidate the mechanism of gelation to maximally control gel t...

Different molecular species of interleukin 1 (IL 1) were examined for the spectrum of responses elicited in human endothelial cells (HEC), including synthesis of prostacyclin (PGI2), tissue-type procoagulant activity (PCA), platelet activating factor (PAF), and plasminogen activator inhibitor (PA-I). The IL 1 preparations utilized for the present study included a natural, partially purified IL ...

The present study was undertaken to further characterize the interaction of monoclonal antibodies (mAbs) against tumor necrosis factor (TNF) receptors with different targets, and to assess their ability to influence TNF effects on U937 and human endothelial cell (HEC) functions. Actions of recombinant TNF-alpha on U937 and HEC were effectively inhibited by Htr-5 and Utr-1, and to a greater exte...

A balance between production and degradation of reactive oxygen species (ROS) is critical for maintaining cellular homeostasis. Increased levels of ROS during oxidative stress are associated with disease conditions. Antioxidant enzymes, such as extracellular superoxide dismutase (EC-SOD), in the extracellular matrix (ECM) neutralize the toxicity of superoxide. Recent studies have emphasized the...

The role, effectiveness, and even existence of hospital ethics committees (HECs) are not universally agreed upon. Over the past 20 years, the study of HECs has focused mainly on their structure, scope, and function, making the results more descriptive than anything. In an effort to present study results that could help HECs better serve the needs of their organizations, the authors of this arti...

It is important to prevent nausea and vomiting to maintain both the quality of life of patients with cancer and the efficacy of chemotherapy. The aim of this study was to examine the efficacy of aprepitant for treatment of chemotherapy-induced nausea and vomiting (CINV) in Japanese patients with gastrointestinal cancer receiving highly or moderately emetogenic chemotherapy (HEC or MEC) regimens...

As indicated by Becker and Watts (2001), teaching in economics and finance is still mostly done in a Chalk and Talk passive learning environment. This paper reports on an active, hands-on approach implemented for business students enrolled in an undergraduate course in options and futures at HEC Montréal. The proposed environment adapts and extends the studio approach first developed for Introd...