Midkine (MK) is a heparin-binding cytokine, and promotes growth, survival, migration and other activities of target cells. After describing the general properties of MK, this review focuses on MK and MK inhibitors as therapeutics for diseases in the central nervous system. MK is strongly expressed during embryogenesis especially at the midgestation period, but is expressed only at restricted si...

در این مقاله یک مدل ریاضی برای مسئله سیستم تولیدی همکارانه ساخت بر اساس سفارش با رعایت انصاف تخصیص بار‌های تولید طراحی شده است. اهداف اصلی مدل، کمینه‌سازی هزینه‌‌های کل و حداکثر استفاده از منابع به‌منظور عادلانه شرایط عدم­قطعیت کنترل پارامتر‌های غیرقطعی روش برنامه‌ریزی فازی ‌شده نتایج نشان می‌دهد افزایش نرخ عدم‌قطعیت، می­یابد. ازآنجاکه ظرفیت کارخانه‌ها ثابت است، مقدار تقاضا، هر کارخانه نیز می­ی...

An integral representation for the functional F(m, M) := inf { lim inf k→+∞ ∫ Ω f(x, mk(x),∇mk(x)) dx + ∫ Ω∩S(mk) |[mk](x)|dH : mk ∈ SBV (Ω;R ), |mk(x)| = 1 a.e. in Ω, mk → m in L(Ω;R ), ∇mk ⇀ M in L(Ω;R ) } . This problem is motivated by equilibria issues in micromagnetics.

In welded tubular joints, when the fatigue crack depth is less than 20% of chord wall thickness, the crack growing process is highly affected by weld geometry.&#10 Hence, T-butt solution and weld magnification factor (Mk) are applicable tools for evaluating the crack growth rate in this domain. In this research, the capability of Artificial Neural Network (ANN) for estimating the Mk of weld toe...

In welded tubular joints, when the fatigue crack depth is less than 20% of chord wall thickness, the crack growing process is highly affected by weld geometry. Hence, T-butt solution and weld magnification factor (Mk) are applicable tools for evaluating the crack growth rate in this domain. In this research, the capability of Artificial Neural Network (ANN) for estimating the Mk of weld toe c...

BACKGROUND Vitamin K₂ contributes to bone and cardiovascular health. Therefore, two vitamin K₂ homologues, menaquinone-4 (MK-4) and menaquinone-7 (MK-7), have been used as nutrients by the food industry and as nutritional supplements to support bone and cardiovascular health. However, little is known about the bioavailability of nutritional MK-4. To investigate MK-4 and MK-7 bioavailability, nu...