objective(s) diabetes related dysfunction of resistance vessels is associated with vascular occlusive diseases. vasorelaxant agents may have a role in control of diabetic cardiovascular complications. gamma aminobutyric acid (gaba) has demonstrated to cause vasorelaxation. the present study was designed to determine i) the vasorelaxatory effect of gaba on diabetic vessels and ii) the role of en...

gamma aminobutyrate (gaba) is a non-protein amino acid that is thought to play an important role in the modulation of the central response to stress. mechanisms by which gaba may facilitate these responses to stress are metabolic and/or mechanical disruptions. environmental stresses increase gaba accumulation through cytosolic acidification, induce an acidic ph-dependent activation of glutamate...

objective(s) indigofera tinctoria linn. of fabaceae family is claimed to be useful to control epileptic seizures in the indian system of folkore medicine. this study was designed to evaluate i. tinctoria and to verify the claim. materials and methods seizures were induced in male albino rats with pentylenetetrazole (ptz). the test group animals were administered ethanolic extract of indigofera ...

Chilling damage under 15ºC in anthurium cut flowers reduces the vase-life, quality and marketability of the product. In the present experiment, GABA postharvest treatment (0, 1 and 5 mM) was studied on the vase-life, total soluble solid (TSS), H2O2 content, proline content, spathe browning, catalase and superoxide dismutase enzymes activity of Anthurium andraeanum...

Accumulation of γ -aminobutyric acid (GABA) is associated with stress factors in plant systems. The objective of the current study was to compare GABA concentration in wheat plants under chilling stress. After 48 h treatments of seedlings under chilling stress combined stresses with and without GABA, morphological and biochemical assays were conducted. It was observed that the inhibition of see...

in plants, γ-aminobutyric acid (gaba) is synthesized by polyamine degradation pathway besides gaba shunt. aminoguanidine (ag) is a specific inhibitor of the key enzyme (diamine oxidase, dao) for gaba formation in polyamine degradation pathway. in this study, ag was applied to study the functions of polyamine degradation pathway on growth and gaba accumulation in germinating fava bean under hypo...

Introduction: Gama amino butyric acid (GABA) is the major inhibitory neurotransmitter in the mammalian nervous system. The concentration of GABA and the number of GABA cell secretion decrease in diabetic patient and experimental diabetes model. The reported effects of GABA activation on insulin secretion from beta cells have been controversial. In this study we investigated if GABA administr...

Objective: GABAergic system is a target for various groups of medications including sedatives, anxiolytics, muscle relaxants, antidepressants and antiepileptics. Several foods or food ingredients are able to affect the by inhibition γ-aminobutyric acid (GABA) degrading enzymes GABA-transaminase succinate semialdehyde dehydrogenase. The purpose this study investigate inhibitory effects tea (Came...