BACKGROUND Fibrinogen (Fg) has been considered essential for platelet aggregation. However, we recently demonstrated formation of occlusive thrombi in Fg-deficient mice and in mice doubly deficient for Fg and von Willebrand factor (Fg/VWF(-/-)). METHODS AND RESULTS Here we studied Fg/VWF-independent platelet aggregation in vitro and found no aggregation in citrated platelet-rich plasma of Fg/...

تصویربرداری مقطع‌نگاری نوترونی یکی از کاربردهای مدرن رآکتورهای تحقیقاتی در سرتاسر جهان به‌شمار می‌رود. تلفیق قابلیت نمایش سه‌بعدی با ویژگی‌های منحصر به فرد برهم‌کنش نوترون مواد، می‌تواند اطلاعات بسیار ارزشمندی ساختار داخلی مواد و تجهیزات را اختیار محققین قرار ‌دهد. این تحقیق، تأثیر هندسه داده‌برداری تجربی روش بازسازی تصویر بر کیفیت تصاویر سامانه رآکتور تهران براساس شاخص وضوح میزان تولید نویز مو...

Haemophilus ducreyi is the etiologic agent of the sexually transmitted genital ulcer disease chancroid. In both natural and experimental chancroid, H. ducreyi colocalizes with fibrin at the base of the ulcer. Fibrin is obtained by cleavage of the serum glycoprotein fibrinogen (Fg) by thrombin to initiate formation of the blood clot. Fg binding proteins are critical virulence factors in medicall...

This study adopts the Keller’s ARCS (Attention, Relevance, Confidence, and Satisfaction) motivational design framework to develop instructional strategies to integrate educational game learning into formal classroom settings. The experimental instruction lasts 8 weeks and there are 103 students in 6 grader involved. From the result of students’ opinions, motivational instruction strategies deve...

Thrombospondin-1 (TSP) may, after secretion from platelet alpha granules, participate in platelet aggregation, but its mode of action is poorly understood. We evaluated the capacity of TSP to form inter-platelet cross-bridges through its interaction with fibrinogen (Fg), using either Fg-coated beads or Fg bound to the activated GPIIbIIIa integrin (GPIIbIIIa*) immobilized on beads or on activate...

The combined efficacy of space- and alertness related training in chronic hemineglect was tested behaviorally and in a longitudinal fMRI study. Earlier results had shown that both space as well as alertness related training as single intervention methods lead to short term improvement which, however, is not stable for longer time periods. The neurobiological data obtained in these studies revea...

BACKGROUND Previous studies have demonstrated that elevated admission and fasting glucose (FG) is associated with worse outcomes in patients with acute myocardial infarction (AMI). However, the quantitative relationship between FG levels and in-hospital mortality in patients with AMI remains unknown. The aim of the study is to assess the prevalence of elevated FG levels in hospitalized Chinese ...

In addition to its pivotal role in hemostasis, fibrinogen (Fg) and provisional fibrin matrices play important roles in inflammation and regulate innate immune responses by interacting with leukocytes. Efb (the extracellular fibrinogen-binding protein) is a secreted Staphylococcus aureus protein that engages host Fg and complement C3. However, the molecular details underlying the Efb-Fg interact...

Magnetic biosensors are an important part of biomedical applications of magnetic materials. As the living tissue is basically a "soft matter." this study addresses the development of ferrogels (FG) with micron sized magnetic particles of magnetite and strontium hexaferrite mimicking the living tissue. The basic composition of the FG comprised the polymeric network of polyacrylamide, synthesized...