Iron is an essential nutrient that functions as a cofactor for cellular enzymatic redox reactions. Hosts and pathogens compete over iron survival. Previous studies have implicated the skin unique site homeostasis major contributing source to excretion from body: Primary human keratinocytes store ferritin function of exogenous addition, with modulation their differentiation. Wildtype mice subjec...

Body odors provide a rich source of sensory information for other animals. There is considerable evidence to suggest that short-term fluctuations in body odor can be caused by diet; however, few, if any, previous studies have demonstrated that specific compounds can directly mask or alter mouse urinary odor when ingested and thus alter another animal's behavior. To investigate whether the inges...

Although anti-PD-1/PD-L1 antibodies represent a major breakthrough in NSCLC patients’ survival, this treatment efficacy is highly dependent on tumor PD-L1 expression. We reported the role of Id1 and combined blockade PD-1-Id1 KRAS mutant mouse model [Baraibar, Cancers 2020]. Trametinib, an oral MEK1/2 inhibitor, acts downstream KRAS. Here we evaluate trametinib as inhibitor able to enhance immu...

Abstract Introduction Neurons in the pre-Bötzinger complex are critical for generation of inspiratory rhythm and control activity genioglossus muscle via activation hypoglossal motoneurons. Activation causes anterior movement tongue widens upper airway. As obstructive sleep apnea (OSA) is associated with obstruction airway, this neuronal pathway may be a novel therapeutic approach. Orexins have...

زمینه و هدف: مجموعة پروتئینی mTOR در پاسخ به تمرینات مقاومتی با رویکردی هیستولوژیکی افزایش هوازی سوخت‌وسازی کاهش می‌یابد. این تغییرات شرایط ابتلا دیابت نوع دو همراه ورزشی می‌تواند قابل بحث باشد. بدین‌منظور لحاظ کردن تمریناتی مانند تمرین تناوبی شدید دارا بودن ویژگی‌های بی‌هوازی از طرفی مداخلة تعامل احتمالی شاخص‌های گلایسمیک هیستوپاتولوژیکی قلب را تصویر بکشد. ازاین‌رو پژوهش حاضر برای تعیین تأثیر ...

Aquaporin-1 (AQP1) is a proangiogenic water channel protein promoting endothelial cell migration. We previously reported that AQP1 silencing by RNA interference reduces angiogenesis-dependent primary tumour growth in a mouse model of melanoma. In this study, we tested the hypothesis that AQP1 inhibition also affects animal survival and lung nodule formation. Melanoma was induced by injecting B1...

Insulin exerts its potent effects on hepatic glucose fluxes via direct and indirect mechanisms. Whereas a liver-specific insulin receptor (IR) knockout (LIRKO) mouse exhibits glucose intolerance as well as insulin resistance, it is unclear whether a more acute decrease in the expression of hepatic IR would be sufficient to induce hepatic insulin resistance. Here we report that the downregulatio...

A diet high in fat induces cardiac hypertrophy, inflammation, and oxidative stress. Although such actions have largely been ascribed to fat deposition, the accumulation of advanced glycation end products (AGEs) and subsequent activation of the receptor for AGEs (RAGE) may also represent important mediators of cardiac injury following exposure to a Western diet. In this study, male C57BL6J and R...

Circadian rhythms are integral to the normal functioning of numerous physiological processes. Evidence from human and mouse studies suggests that loss of rhythm occurs in obesity and cardiovascular disease and may be a neglected contributor to pathophysiology. Obesity has been shown to impair the circadian clock mechanism in liver and adipose tissue but its effect on cardiovascular tissues is u...