IL-23 and IL-12 are heterodimeric cytokines which share the p40 subunit, but which have unique second subunits, IL-23p19 and IL-12p35. Since p40 is required for the development of the Th1 type response necessary for resistance to Toxoplasma gondii, studies were performed to assess the role of IL-23 in resistance to this pathogen. Increased levels of IL-23 were detected in mice infected with T. ...

Psoriasis is a chronic, immune-mediated disease affecting more than 100 million people worldwide and up to 2.2% of the UK population. The aetiology of psoriasis is thought to originate from an interplay of genetic, environmental, infectious and lifestyle factors. The manner in which genetic and environmental factors interact to contribute to the molecular disease mechanisms has remained elusive...

BACKGROUND Uveitis is an eye inflammatory disease, which is sometimes associated with underlying systemic disease. Interleukin-23 plays an important role in autoimmune disease. The aim of this meta-analysis was to evaluate the association between the interleukin-23 receptor (IL-23R) and susceptibility to uveitis. METHODS Published literature from PUBMED and EMBASE were retrieved. Seven studie...

George Palade's pioneering work in the 1960s had established the secretory pathway and its connection to the biogenesis of organelles as a major theme in eukary-otic cell biology (Palade, 1975). His disciples, including David Sabatini and Gunter Blobel, extended Palade's morphological approaches to the next level of analysis, involving subcellular fractionation and biochemical re-constitution t...

Adolescents in the ninth grade (n=75) responded to a hypothetical situation involving an individual who neglects their friend as a result of their transition to steady dating. Results indicated that 53 per cent of girls and 32 per cent of boys reported past personal exclusion by their best friend who they perceived to be preoccupied by a romantic partner. Only 21 per cent of girls and 19 per ce...

Our previously conducted pharmacological screening led as to the discovery of the strong local anesthetic activity of the compound designated as KP-23. Earlier crystallographic studies revealed that the compound KP-23 crystallized in diastereoisomeric form in lowest symmetry. The aim of these comparative investigations was to evaluate anesthetic activity of KP-23 and its R,S-diastereoisomers, w...

IL-23 is a heterodimeric cytokine composed of the IL-12p40 "soluble receptor" subunit and a novel cytokine-like subunit related to IL-12p35, termed p19. Human and mouse IL-23 exhibit some activities similar to IL-12, but differ in their capacities to stimulate particular populations of memory T cells. Like IL-12, IL-23 binds to the IL-12R subunit IL-12Rbeta1. However, it does not use IL-12Rbeta...