نتایج جستجو برای: ژن calhm1
تعداد نتایج: 15840 فیلتر نتایج به سال:
In a recent paper in Cell, Dreses-Wer-ringloer et al. (2008) reported the identification and functional characterization of a new Alzheimer's disease (AD) gene, CALHM1, encoding calcium homeostasis modulator 1. CALHM1 (formerly annotated as FAM26C) represents a compelling candidate gene for late-onset AD as it is located on chromosome 10q24, a consistently replicated AD linkage region (Bertram ...
ranging from 0.15 to 0.84). Stratification by age of AD onset (using 65 years as cutoff) or APOE ε4-genotype did not appreciably change these results (data not shown; stratified analyses were not possible in the GWAS samples as no onset age or APOE ε4 data were supplied). Effect size estimates indicated insignificant ORs that were opposite in direction to those reported by Dreses-Werringloer et...
Recent developments point to a critical role for calcium dysregulation in the pathogenesis of Alzheimer's disease. A novel calcium-conducting channel called CALHM1 is genetically linked to the disorder and modulates Abeta production. Calcium homeostasis has also been shown to be perturbed in dendritic spines adjacent to amyloid plaques. Finally, new studies have elucidated the role by which pre...
Adenosine triphosphate (ATP) has been well established as an important extracellular ligand of autocrine signaling, intercellular communication, and neurotransmission with numerous physiological and pathophysiological roles. In addition to the classical exocytosis, non-vesicular mechanisms of cellular ATP release have been demonstrated in many cell types. Although large and negatively charged A...
اثرات متقابل پلی مورفیسم های ژنتیکی از عوامل مهم ابتلا به بیماری های پیچیده نظیر آلزایمر است. در مطالعات وابستگی ژنتیکی تعیین ترکیبی از پلی مورفیسم ها و اندازه گیری میزان اهمیت آن ها در افزایش خطر بروز چنین بیماری هایی مدنظر است. هدف این تحقیق استفاده از رویکرد خصیصه گزینی رگرسیون منطقی در شناسایی اثرات متقابل پلی مورفیسم های ژنتیکی موثر در ابتلا به آلزایمر بوده است. در یک بررسی مقطعی، 101 سال...
نمودار تعداد نتایج جستجو در هر سال
با کلیک روی نمودار نتایج را به سال انتشار فیلتر کنید