نتایج جستجو برای: ژن il6
تعداد نتایج: 18418 فیلتر نتایج به سال:
Elevated levels of the proinflammatory cytokine IL6 are associated with poor survival outcomes in many cancers. Antibodies targeting IL6 and its receptor have been developed for chronic inflammatory disease, but they have not yet been shown to clearly benefit cancer patients, possibly due to antibody potency or the settings in which they have been tested. In this study, we describe the developm...
Background Nutritional disorders are plurifactorial diseases in which the genetic aspects have an important role near the lifestyle and dietary habits. The systemic inflammation and cytokines levels are much studied in the etipatogenity of these diseases. We aimed to assess the relation between IL6-174G/C,IL6-190T/C andIL6-572G/C genes polimorphisms and nutritional status in a group of pediatri...
The cells that make up blood vessel walls appear to participate actively in local immune and inflammatory responses, as well as in certain vascular diseases. We tested here whether smooth muscle cells (SMC) can produce the important inflammatory mediator IL6. Unstimulated SMC in vitro elaborated 5 X 10(3) pg recIL6/24h (i.e., biological activity equivalent to 5 X 10(3) pg recombinant IL6 (recIL...
Elevated levels of the proinflammatory cytokine IL6 are associated with poor survival outcomes in many cancers. Antibodies targeting IL6 and its receptor have been developed for chronic inflammatory disease, but they have not yet been shown to clearly benefit cancer patients, possibly due to antibody potency or the settings in which they have been tested. In this study, we describe the developm...
Pregnancy is associated with hyperphagia, increased adiposity and multiple neuroendocrine adaptations. Maternal adipose tissue secretes rising amounts of interleukin 6 (IL6), which acts peripherally modulating metabolic function and centrally increasing energy expenditure and reducing body fat. To explore the role of IL6 in the central mechanisms governing dam's energy homeostasis, early, mid a...
IL6-PE40 and IL6-PE664G'" are chimeric molecules composed of interleukin 6 (11.6) fused to a truncated form (PE40) or a full-length mutated form (PE664GI")of Pseudomonas exotoxin. Both forms of IL6Pseudomonas exotoxin are cytotoxic to IL6 receptor-bearing tumor cell types in culture. In this report, we show that both IL6-PE40 and IL6I'l .(•><>"''" have antitumor activity against the hepatocel...
We have probed for the presence of interleukin 6 (IL6) receptors in prostatic carcinoma cell lines (LNCaP, DU 145, and PC3) by examining their sensitivity to the cytotoxic effects of a chimeric toxin composed of IL6 and Pseudomonas exotoxin (PE). All three cell lines were killed by IL6-PE66(4)Glu, a version of IL6-PE in which the binding domain of native PE has been mutated to debilitate PE bin...
مقدمه بیماری مزمن کلیه (CKD) یک اختلال پیشرونده کلیه است که بیش از 3 ماه طول کشیده است. سطح بالای سایتوکاینهایی نظیر اینترلوکین 6 (IL6) واینترکولین 10 (IL10) به عنوان فاکتورهای خطر مستقل برای موربیدیتی و مورتالیتی و بیماران CKD تعریف شدهاند. هدف مطالعه ارزیابی فاکتورهای پیش بینی کننده سطح IL6 و IL10 در بیماران همودیالیزی بود روش کار در این مطالعه مقطعی ،بیمارانی که در زمستان1392به مرکز ...
Interleukin-6 (IL6) is encoded by the IL6 gene in human and acts as pro-inflammatory cytokine and an anti-inflammatory cytokine. Recent studies established that IL6 substantially contribute in the diagnosed of systemic inflammation for the patients suffering from lung diseases such as chronic obstructive pulmonary disease (COPD). Thereof, this work aimed to investigate the prot...
Interleukin 6 (IL6) mediates pleiotropic physiological functions through its interaction with the IL6 receptor (IL6R). Signal transduction can occur via cis- and trans-signaling. The role of IL6/IL6R interaction via autocrine and paracrine loops in tumor proliferation and progression is discussed. The potential role of IL6/IL6R interaction in different experimental systems and tumor entities is...
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