IKK/NF-kB signalling controls inflammation and cell death is important to maintain tissue homeostasis. Keratinocyte-specific deletion of IKK2 (IKK2E-KO) leads TNFR1-dependent skin in mice. IKK2E-KO mice showed increased numbers apoptotic necrotic keratinocytes, upregulation inflammatory cytokines mediators the epidermis. We proposed that keratinocyte could trigger inflammation. Receptor Interac...

     It has been proposed that organic nitrates such as glyceryl trinitrate (GTN), used in the treatment of cardiovascular diseases, act by producing nitric oxide (NO). However, the biochemical pathway for NO formation from GTN is not well understood. In the present study, we showed that nitrate formation from GTN, by isolated rat hepatocytes, was inhibited about 50% when cellular glutathione w...

Abstract INTRODUCTION Mouse models are instrumental in advancing our understanding of glioblastoma (GBM), however many commonly used have features that limit their practicality or applicability. These limitations can include an incomplete immune context, a requirement for complex breeding strategies, high cost specialized lines, and unpredictability where tumors arise. We sought to develop vali...