نتایج جستجو برای: ژن lrp4
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Lrp4 is a multifunctional member of the low density lipoprotein-receptor gene family and a modulator of extracellular cell signaling pathways in development. For example, Lrp4 binds Wise, a secreted Wnt modulator and BMP antagonist. Lrp4 shares structural elements within the extracellular ligand binding domain with Lrp5 and Lrp6, two established Wnt co-receptors with important roles in osteogen...
The extent to which cell signaling is integrated outside the cell is not currently appreciated. We show that a member of the low-density receptor-related protein family, Lrp4 modulates and integrates Bmp and canonical Wnt signalling during tooth morphogenesis by binding the secreted Bmp antagonist protein Wise. Mouse mutants of Lrp4 and Wise exhibit identical tooth phenotypes that include super...
Introduction: Endochondral ossification is one of the essential processes during skeletal bone system development, which requires chondrogenesis accompanies with proper extracellular matrix production. Recently, regulation of chondrogenesis by Wnt signaling has been extensively studied and some of Wnt signaling components are known to regulate endochondral ossification [1]. However, the underly...
BACKGROUND Myasthenic symptoms can be present in patients with amyotrophic lateral sclerosis (ALS). These symptoms have been considered to be caused by the degeneration of distal motor neurons and the neuromuscular junction (NMJ). Recent studies suggested that antibody to low-density lipoprotein receptor-related protein 4 (LRP4) was a pathogenic agent of myasthenia gravis (MG), and it was also ...
Mulefoot disease (MFD) is an autosomal recessive disorder of phenotypically variable expression that causes syndactyly in certain strains of cows. MFD maps to a narrow interval on bovine chromosome 15 that is syntenic to human chromosome 11p12-p11.2. This region contains MEGF7/LRP4 (approved gene symbol LRP4), a gene that encodes a member of the multifunctional low-density lipoprotein receptor ...
BACKGROUND Development of the kidney is initiated when the ureteric bud (UB) branches from the Wolffian duct and invades the overlying metanephric mesenchyme (MM) triggering the mesenchymal/epithelial interactions that are the basis of organ formation. Multiple signaling pathways must be integrated to ensure proper timing and location of the ureteric bud formation. METHODS AND PRINCIPAL FINDI...
Submit Manuscript | http://medcraveonline.com Abbreviations: NMJD: Neuromuscular Junction Disorders; ENG: Electro Neurography; EMG: Electro Myography; RNS: Repetitive Nerve Stimulation; SFEMG: Single Fiber ElectroMyoGraphy; AChR Ab: AcetylCholine Receptor Antibody; anti-MuSk Ab: antiMuscle Specific kinase Antibody; TA: Tyro Arythenoid muscle; CMAP: Compound Motor Action Potential; Lrp4 Ab: Lipo...
A variable proportion of patients with generalized myasthenia gravis (MG) have autoantibodies to muscle specific tyrosine kinase (MuSK). During development agrin, released from the motor nerve, interacts with low density lipoprotein receptor-related protein-4 (LRP4), which then binds to MuSK; MuSK interaction with the intracellular protein Dok7 results in clustering of the acetylcholine recepto...
Changes in tooth shape have played a major role in vertebrate evolution with modification of dentition allowing an organism to adapt to new feeding strategies. The current view is that molar teeth evolved from simple conical teeth, similar to canines, by progressive addition of extra "cones" to form progressively complex multicuspid crowns. Mammalian incisors, however, are neither conical nor m...
#### Notable in Neurology This Week issue features an article that explores the experiences of community neurologists as they treated neurodegenerative illnesses during coronavirus disease 2019 (COVID-19) pandemic; another determines associations between long-term dietary flavonoids and subjective cognitive decline. A featured Viewpoint discusses ethical guidance for designing clinical trials f...
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