Nerve growth factor (NGF) is a neurotrophic factor that is functional in the survival, maintenance and differentiation of nervous system cells. This protein has three subunits, of which the beta subunit has the main activity. Its structure consists of a cysteine knot motif made up of beta strands linked by disulfide bonds. It can be used as a therapeutic agent in the treatment of many diseases....

Introduction: Carbon nanotubes (CNTs) have shown enormous potential in neuroscience. Nerve growth factor (NGF)-CNTs complex promotes the neuronal growth, however, the underlying mechanism(s) have remained elusive. Based on the interplay between NGF and the endocannabinoid system, involvement of the neuroprotective endocannabinoid, 2-arachidonoyl glycerol (2-AG), was investigated in the mechanis...

Introduction: Ferulic acid, a phenolic phytochemical with neuroprotective, anti-inflammatory, and antioxidant properties, has shown promising antidepressant-like effects in behavioral studies; however, its mechanism(s) of action have not been fully understood. Based on the contribution of nerve growth factor (NGF) and endocannabinoid signaling (eCBs) to the emotional or antidepressant activ...

Introduction: Psychotropic drugs exert their effects, in part, by increasing neurotrophin levels in the brain. Nerve growth factor (NGF) protein levels after treatment with only a limited number of psychotropics have been determined. The present study was designed in order to evaluate the effects of acute and chronic administration of different psychotropic drugs on NGF protein levels in fiv...

introduction: carbon nanotubes (cnts) have shown enormous potential in neuroscience. nerve growth factor (ngf)-cnts complex promotes the neuronal growth, however, the underlying mechanism(s) have remained elusive. based on the interplay between ngf and the endocannabinoid system, involvement of the neuroprotective endocannabinoid, 2-arachidonoyl glycerol (2-ag), was investigated in the mechanis...

Background Cholinergic innervation is particularly vulnerable in many neurodegenerative diseases associated with cognitive dysfunction, and loss of cholinergic neurons Alzheimer’s disease (AD) pathogenic event observed from early stage correlated impairment. Nerve growth factor (NGF) plays a major role the maintenance function neurons, decrease trophic signalling by NGF-Tropomyosin receptor kin...

Neurite outgrowth from dorsal root ganglion (DRG) explants is a method of evaluating neurotrophic activity of growth factors. When complete medium containing collagen was supplemented with nerve growth factor (NGF) DRG outgrowth was observed after 18 h. In the absence of NGF and in the presence of collagen, the DRG outgrowth took place after 72 h. In wells not supplemented with collagen gel in ...

Abstract We construct localized beams in a non-Hermitian Glauber Fock (NGF) lattice of coupled waveguides and show that they can propagate over long distance withalmost no diffraction. specifically obtain the diffraction-free finite NGF at exceptional point (EP) by using exact eigenstates semi-infinite unidirectional lattice. provide numerical approach to finding other lattices are capable supp...