BACKGROUND Osteopontin (OPN) is identified as one of the leading genes that promote the metastasis of malignant tumor through binding to CD44v6 and integrin. The purpose of the current study was to assess the prognostic significance of OPN and CD44v6 in patients with non-small cell lung cancer (NSCLC). METHODS Tissue microarray was used to detect the expression of OPN and CD44v6 in 159 NSCLC ...

In the hepatocellular carcinoma (HCC) microenvironment, chemokine receptors play a critical role in tumorigenesis and metastasis. Our previous studies have found that osteopontin (OPN) is a promoter for HCC metastasis. However, the role of chemokine receptors in OPN-induced HCC metastasis remains unclear. In this study, we demonstrate that OPN is dramatically elevated in HCC tissues with metast...

Objective Osteopontin (Opn) is one of the co-factors which participates in cell adhesion and invasion during implantation process. Increased incidence of spontaneous abortion is reported in diabetic women. Several reports have shown Opn gene expression changes in diabetic condition in several tissues. Therefore, this study was designed to evaluate the effects of diabetes on Opn gene expression ...

NEW FINDINGS What is the central question of this study? What is the functional relevance of OPN isoform expression in muscle pathology? What is the main finding and its importance? The full-length human OPN-a isoform is the most pro-inflammatory isoform in the muscle microenvironment, acting on macrophages and myoblasts in an RGD-integrin-dependent manner. OPN-a upregulates expression of tenas...

quantitative trait loci (qtl) affecting milk production traits on bovine chromosome 6 close to the opn gene location have been identified through several whole genome scans. opn is a phosphoprotein, synthesized in a variety of tissues and cells and secreted into body fluids. in this study, dna was isolated from blood samples collected from 398 holstein cows in tehran and esfahan provinces. dna ...

Calciumoxalat ist der Hauptbestandteil von Nierensteinen. Das saure Osteopontin (OPN)-Protein im Urin kann das Wachstum CaC2O4-Kristallen hemmen und wirkt so als Inhibitor Mineralisation. Studien in Bulk-Lösung belegten die Wichtigkeit Bindung Erkennung OPN an CaC2O4-Mineraloberfläche, allerdinngs fehlen noch Einblicke aktive Zentrum auf molekularer Ebene während CaC2O4-Mineralisierung. Wir stu...

Osteopontin (OPN) is an osteogenic marker protein. Osteoblast functions are affected by inflammatory cytokines and pathological conditions. OPN is highly expressed in bone lesions such as those in rheumatoid arthritis. However, local regulatory effects of OPN on osteoblasts remain ambiguous. Here we examined how OPN influences osteoblast responses to mechanical stress and growth factors. Expres...

Osteopontin (OPN) is a secreted acidic phosphoprotein that binds to a cell-surface integrin-binding motif and is involved in many inflammatory and immune-modulating disorders. There is compelling evidence that soluble OPN can in a variety of situations help cells survive an otherwise lethal insult. In this study we show that OPN is localized in the rat pancreatic islets and ducts. Staining of p...

Osteopontin (OPN) is known to be overexpressed in numerous carcinomas. Although abundant OPN has been reported to be correlated with poor survival in non-small cell lung cancer (NSCLC) but their clinical and prognostic significance in SCLC remains unknown. In this study, RNA-sequencing was used to obtain gene expression data in SCLC tissue samples and OPN expression levels were then investigate...

Increased osteopontin (OPN) expression associates with increased myocyte apoptosis and myocardial dysfunction. The objective of this study was to identify the receptor for OPN and get insight into the mechanism by which OPN induces cardiac myocyte apoptosis. Adult rat ventricular myocytes (ARVMs) and transgenic mice expressing OPN in a myocyte-specific manner were used for in vitro and in vivo ...