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Background and purpose: Non selective non-steroidal anti-inflammatory drugs and ciclooxygenase 2 inhibitors provide symptoms relief in osteoarthritis (OA), but produce several adverse effects (AE), which supports the search for other options. D-002, a mixture of higher aliphatic beeswax alcohols, has been shown to produce anti-inflammatory effects experimentally. This double-blind study investi...
Bypassing tyrosine kinases responsible for Stat5a/b phosphorylation would be advantageous for therapy development for Stat5a/b-regulated cancers. Here, we sought to identify small molecule inhibitors of Stat5a/b for lead optimization and therapy development for prostate cancer and Bcr-Abl-driven leukemias. In silico screening of chemical structure databases combined with medicinal chemistry was...
The response of atmospheric CO2 and climate to the reconstructed variability in solar irradiance and radiative forcing by volcanoes over the last millennium is examined by applying a coupled physical-biogeochemical climate model that includes the Lund-Potsdam-Jena dynamic global vegetation model (LPJ-DGVM) and a simplified analogue of a coupled atmosphere-ocean general circulation model. The mo...
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