نتایج جستجو برای: 003 day
تعداد نتایج: 346450 فیلتر نتایج به سال:
Patients with chronic pain commonly report sleep problems, and the evidence for a relationship between disturbance seems robust. The day-to-day associations these constructs are less well studied, particularly objective measures such as actigraphy. Moreover, concurrent presence of negative affective symptoms, seasonality effects at extreme latitudes may complicate it further. Here, we studied 5...
1Department of Biochemistry, King George’s Medical University, Lucknow-226 003, India 2Department of Pediatric Surgery, Institute of Medical Sciences, Banaras Hindu University, Varanasi221005, India 3Department of Orthopedic Surgery, King George’s Medical University, Lucknow-226 003, India 4Department of Transfusion Medicine, King George’s Medical University, Lucknow-226 003, India 5Department ...
The ubiquitin-proteasome pathway regulates bone formation through osteoblast differentiation. We analyzed variation alkaline phosphatase (ALP) during carfilzomib treatment. Data from 38 patients enrolled in the PX-171-003 and 29 patients in PX-171-004 studies, for patients with relapsed/refractory myeloma, were analyzed. All patients received 20 mg/m(2) of carfilzomib on Days 1, 2, 8, 9, 15, an...
Phytocannabinoids that do not produce psychotropic effects are considered of special interest as novel therapeutic agents in CNS diseases. A cannabigerol quinone, the compound VCE-003, has been shown to alleviate symptoms in a viral model of multiple sclerosis (MS). Hence, we studied T cells and macrophages as targets for VCE-003 and its efficacy in an autoimmune model of MS. Proliferation, cel...
NB-003 and NB-003 gel formulations are oil-in-water nanoemulsions designed for use in bacterial infections. In vitro susceptibility of Propionibacterium acnes to NB-003 formulations and comparator drugs was evaluated. Both NB-003 formulations were bactericidal against all P. acnes isolates, including those that were erythromycin, clindamycin, and/or tetracycline resistant. In the absence of seb...
Both policosanol and D-003 are mixtures of higher aliphatic alcohols and acids, respectively, purified from sugarcane wax, whose main components are octacosanol and octacosanoic acid (an active metabolite of octacosanol), respectively. Both substances share some, not all, pharmacological effects, like cholesterol-lowering, antiplatelet and antioxidant effects. The mechanisms whereby they exhibi...
OBJECTIVES To analyze the postoperative complications and mortality for oral cavity cancers, their time course, and to identify modifiable risk factors associated with their occurrence. STUDY DESIGN Retrospective cohort study. METHODS Patients undergoing surgery for oral cavity cancer were identified in the American College of Surgeons National Surgical Quality Improvement Program Participa...
PURPOSE Cancer cells are highly dependent on folate metabolism, making them susceptible to drugs that inhibit folate receptor activities. Targeting overexpressed folate receptor alpha (FRα) in cancer cells offers a therapeutic opportunity. We investigated the functional mechanisms of MORAB-003 (farletuzumab), a humanized mAb against FRα, in ovarian cancer models. EXPERIMENTAL DESIGN We first ...
A multi-clinic, investigator blinded, randomized, prospective field trial enrolling 379 dogs compared deracoxib and firocoxib administered orally over 30 days to treat musculoskeletal disorders considered by the veterinary investigator as caused by osteoarthritis (OA). Over 60% of dogs improved within 7 days of treatment initiation (Day 0), and improvement over baseline was greater at Day 28 th...
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