Systemic sclerosis (SSc) is a systemic autoimmune disease characterized by excessive fibrosis of the skin and internal organ. FcγRIIB, low-affinity receptor for Fc fragment IgG, expressed on surface several leukocyte subsets functions in negative feedback pathways to down-regulate B cell antigen signaling. To elucidate role FcγRIIB development fibrosis, murine bleomycin (BLM)-induced scleroderm...

Introduction Chronic recurrent multifocal osteomyelitis (CRMO) is an autoinflammatory bone disorder that manifests as recurrent flares of inflammatory bone pain, related to one or more foci of nonbacterial osteomyelitis. Patients may present with low grade fever and modest elevation of the erythrocyte sedimentation rate (ESR), C-reactive protein (CRP) and white blood cell counts (WBC). We descr...

THIS panel was developed to quantify natural killer (NK) cell subsets in Rhesus macaques (Macaca mulatta) during SIVmac239 infection induced pathogenesis. It includes markers to monitor changes in the activation/proliferation phenotype of up to 12 NK cell populations. The performance of the staining was tested on cryopreserved lymph node samples, and on fresh and cryopreserved peripheral blood ...

In this paper we investigate the application of generalized polynomial chaos (gPC) for optimal control based aircraft safety assessment with parameter uncertainties. The approach is based on the formulation of an appropriate optimal control problem to obtain worst case inputs. The criterion to be assessed is introduced in the cost function and the numerical solution is obtained using direct opt...

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