OBJECTIVE To determine the relative risk associated with DPA1 and DPB1 alleles and haplotypes in type 1 diabetes. RESEARCH DESIGN AND METHODS The frequency of DPA1 and DPB1 alleles and haplotypes in type 1 diabetic patients was compared to the family based control frequency in 1,771 families directly and conditional on HLA (B)-DRB1-DQA1-DQB1 linkage disequilibrium. A relative predispositional...

BACKGROUND Type 1 diabetes (T1D) is a multifactorial autoimmune disorder where interaction and integration of immune response genes along with environmental factors play a role in autoimmune destruction of the insulin producing Pancreatic Beta cells. METHODOLOGY/PRINCIPAL FINDINGS We have studied four single nucleotide polymorphisms (FokI site in Exon 2, BsmI and ApaI sites in Intron 8 and Ta...

OBJECTIVE To investigate the association between HLA class II alleles and autoimmune hepatitis (AIH) type I in Thai patients. MATERIAL AND METHOD The clinical data of 50 autoimmune hepatitis patients type I (AIH) at Siriraj hepatitis clinic were analysed, 37 of whom were tested for HLA class II genotyping using polymerase chain reaction and sequence-specific oligonucleotide technique (PCR-SSO...

From the Segawa Neurological Clinic for Children, Tokyo, Japan. Received: Sep. 28, 2007; Accepted: Apr. 29, 2008 Correspondence to: Dr. Masaya Segawa, Segawa Neurological Clinic for Children. 2-8 Surugadai Kanda, Chiyoda-ku, Tokyo 1010062, Japan. Tel.: 81-3-3294-0371; Fax: 81-3-3294-0290; E-mail: [email protected] Autosomal Dominant GTP Cyclohydrolase I (AD GCH 1) Deficiency (Segawa Disea...

OBJECTIVE The aim of this study was to evaluate the association of human leukocyte antigen (HLA)-DQ and HLA-DQA1/DQB1 alleles with Vogt-Koyanagi-Harada (VKH), providing further evidences on the genetic background of this disease. METHODS A comprehensive literature search was conducted on the relationship of HLA-DQ and/or HLA-DQA1/DQB1 alleles with VKH through PubMed, Embase, Cochrane Library,...

Objective: To define the prevalence of auto antibodies (Ab) to different organs in young patients with type 1 diabetes (type 1DM). Methods: Ab to thyroid, celiac and adrenal disease was analyzed in 831 type 1 DM patients. Results: Hundred twenty-three (14.8%) had positive thyroid Ab. The risk of developing thyroid Ab was increased in girls (HR 2.3; 95% CI 1.6 3.2, p < 0.0001). Thirty-three (3.9...

background: cholecystitis is one of the major digestive diseases. its prevalence is particularly high in some populations. significant risk factors associated with cholecystitis include age, sex, obesity, diet, parity and type 2 diabetes. objective: to determine the association between hla-drb1 and cholecystitis. methods: this casecontrol study included forty iraqi arab patients who had cholecy...

Identification of CTL epitopes correlated to immune protection is important for the development of vaccines that enhance T-cell mediated immune responses. The correlation of positively selected amino acids (PS) of HIV-1 with host HLA alleles can identify regions containing potential T-cell epitopes. However, the specific epitopes have to be identified and characterized using overlapping peptide...

BACKGROUND A single nucleotide polymorphism (SNP), upstream of the IL28B gene has been recently associated with natural clearance of HCV. In a well-characterized cohort of patients with thalassaemia major exposed to the risk of acquiring HCV infection by blood transfusions, we aimed to replicate this finding and to evaluate whether combining the IL28B genotype and HLA class II alleles allow vir...

1 Department of Computer Science, University of Alabama, Tuscaloosa, AL, 35487-0290, { cordes | parrish } @cs.ua.edu Abstract  The Department of Computer Science at the University of Alabama has undergone significant revisions in its introductory course sequence for computing majors. This included the construction of a new technology-enabled classroom and a complete shift in the instructional ...