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SBS0335-052 is a blue compact dwarf galaxy (BCD) with one of the lowest known metallicities, Z∼Z⊙/41, making it a local example of how primordial starburst galaxies and their precursors might appear. A spectrum obtained with the Infrared Spectrograph (IRS) on the Spitzer Space Telescope clearly shows silicate absorption features, emission lines of [SIV] and [NeIII], and puts strong upper limits...
BACKGROUND The TLR7/8 agonist 3M-052 and the TLR9 agonist CpG ODN both trigger innate immune responses that support the induction of tumor-specific immunity. Previous studies showed that these agonists used individually could improve the survival of mice challenged with small tumors but were of limited therapeutic benefit against large/advanced tumors. METHODS Normal mice were challenged with...
Since 1997, highly pathogenic avian influenza viruses of the H5N1 subtype have been transmitted from avian hosts to humans. The severity of H5N1 infection in humans, as well as the sporadic nature of H5N1 outbreaks, both geographically and temporally, make generation of an effective vaccine a global public health priority. An effective H5N1 vaccine must ultimately provide protection against vir...
For nearly a century, aluminum salts have been the most widely used vaccine adjuvant formulation, and have thus established a history of safety and efficacy. Nevertheless, for extremely challenging disease targets such as tuberculosis or HIV, the adjuvant activity of aluminum salts may not be potent enough to achieve protective efficacy. Adsorption of TLR ligands to aluminum salts facilitates e...
Understanding how galaxies formed their first stars is a vital cosmological question, but the study of high-redshift objects, caught in the act of forming their first stars, is difficult. Here we argue that two extremely low-metallicity Blue Compact Dwarf galaxies (BCDs), I Zw 18 and SBS 0335-052, could be local templates for primordial star formation, since both lack evolved (> 1Gyr) stellar p...
We present high-resolution radio continuum observations of the nascent starburst in the metalpoor galaxy SBS 0335−052. These radio data were taken with the Very Large Array and include observations at 0.7 cm, 1.3 cm, 2 cm, 3.6 cm, and 6 cm. These observations enable us to probe the thermal radio nebulae associated with the extremely young star-forming regions in this galaxy. Two discrete and lu...
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