BACKGROUND Treating symptoms and preventing exacerbations are key components of chronic obstructive pulmonary disease (COPD) long-term management. Recently, a more tailored treatment approach has been proposed, in particular for two well-established clinical phenotypes, frequent exacerbators and chronic bronchitis-dominant COPD. ELOM-080 has demonstrated clinical efficacy in treating symptoms a...

RY-080 (ethyl 8-ethynyl-5,6-dihydro-5-methyl-6-oxo-4H-imidazo[1,5-a][1,4]benzodiazepine-3-carboxylate) is an imidazobenzodiazepine with 40–50-fold higher affinity for the benzodiazepine binding site of α5rather than α1-, α2or α3-containing GABAA receptors. Previous data describing RY-080 as being convulsant suggests that inverse agonists selective for the α5 subtype may not be suitable for clin...

We present results from multi-epoch spectral analysis of XMM-Newton and Chandra observations of the mini broad absorption line (BAL) quasar PG 1115+080. This is one of the few X-ray detected mini-BAL quasars to date that is bright enough in the X-ray band, mostly due to large gravitationallensing magnifications, to allow in-depth spectral analysis. The present XMM-Newton observations of PG 1115...

This report documents the results of two follow-up workshops on the International Handbook of Labour Market Policy and Evaluation. The aim of these workshops was the exchange of experience among academics and practitioners in the evaluation of labour market policies. The Handbook project as well as the two workshops were supported from the beginning by DG V of the European Commission through th...

Address for correspondence: Prof. Luigi Macchia MD, PhD, Department and School of Allergology and Clinical Immunology, University of Bari – Aldo Moro, Piazza Giulio Cesare, Policlinico, 70124 Bari, Italy, phone: +39 080 5478817, fax: +39 080 5593688, e-mail: [email protected] Received: 30.01.2014, accepted: 29.04.2014 Long-term treatment of refractory severe chronic urticaria by omalizumab...

A correction to this paper has been published: https://doi.org/10.1007/JHEP10(2020)097

1 Central Animal Facility, Indian Institute of Science, Bangalore-560 012, India. 2 Anjuman Arts, Sciences & Commerce College, Bijapur-586101, India. 3 Research Centre, Electron Microscope Unit, # 5, College of Science, King Saud University, P.O. Box 2455, Riyadh 11451, Kingdom of Saudi Arabia. 4 Centre for Sustainable Technologies, Indian Institute of Science, Bangalore-560 012, India. * Corre...

* Corresponding author. Maria De Angelis, Dipartimento di Protezione delle Piante e 13 Microbiologia Applicata, Facoltà di Scienze Biotecnologiche di Bari, Via G. Amendola 165/a, 14 70126 Bari, Italy. Phone: ++ 39 080 5442948; Fax: ++ 39 080 5442911; E-mail: 15 [email protected] 16 17 AC CE PT ED Copyright © 2007, American Society for Microbiology and/or the Listed Authors/Institutions. ...