The PI3K/AKT pathway plays an important role in the initiation and progression of cancer, and the drug development efforts targeting this pathway with therapeutic interventions have been advanced by academic and industrial groups. However, the clinical outcome is moderate. Combination of inhibition of PI3K/AKT and other targeted agents became a feasible approach. In this study we assessed the c...

Clostridium difficile is the commonest cause of antibiotic-associated diarrhoea, with the hospitalized elderly being at particular risk. The organism makes a crystalline surface protein layer (S-layer), encoded by the slpA gene, the product of which is cleaved to give two mature peptides which associate to form the layer. The larger peptide (high molecular weight; HMW), derived from the C-termi...

El objetivo de la investigación fue conocer relación entre el estilo motivacional del docente y satisfacción académica en los estudiantes dos universidades privadas Lima, Perú; contexto educación virtual. La cuantitativa, correlacional, no experimental e involucró 776 facultad ingeniería. Se observó una positiva significativa que fomenta autonomía (.538), mientras control obtuvo negativa con (-...

A comparison of the kinetics of the sorption of copper(II) on to peat from aqueous solution at various initial copper(II) concentrations and peat doses was made. The Elovich model and the pseudo-second order model both provided a high degree of correlation with the experimental data for most of the sorption process. There was a small discrepancy at the initial stages of sorption which suggested...

Abstract Introduction Sexuality is complex and multifaceted, broadly composed of psychological, physiological, interpersonal, identity, social/political phenomena. The term “sexuality” used inconsistently in the literature, both how it defined by researchers measured. Some define sexuality a narrow, heteronormative, genital-focused way that negates subjective experiences individuals, turn, affe...