نتایج جستجو برای: 099 and r2 094
تعداد نتایج: 16831796 فیلتر نتایج به سال:
Nonsteroidal anti-inflammatory drugs (NSAIDs) have shown promise in colorectal cancer (CRC), but they are compromised by gastrotoxicity. NO-NSAIDs are hybrid nitrates conjugated to an NSAID designed to exploit the gastroprotective properties of NO bioactivity. The NO chimera ethyl 2-((2,3-bis(nitrooxy)propyl)disulfanyl)benzoate (GT-094), a novel nitrate containing an NSAID and disulfide pharmac...
The c-Myc (Myc) oncoprotein is a high-value therapeutic target given that it is deregulated in multiple types of cancer. However, potent small molecule inhibitors of Myc have been difficult to identify, particularly those whose mechanism relies on blocking the association between Myc and its obligate heterodimerization partner, Max. We have recently reported a structure-activity relationship st...
Leaf early senescence caused by nutrition deficiency is one of the major limitation reasons in the world crop production. Potassium (K) is one of important nutrient elements in crop growth, which modifies dozens of enzyme activations and controls stomatal movement of photosynthesis. The yield and quality of maize (Zea Mays L.) have been limited due to K deficiency in plough layer soil. However,...
Long-acting anti-HIV products can substantively change the standard of care for patients with HIV/AIDS. To this end, hydrophobic antiretroviral drugs (ARVs) were recently developed for parenteral administration at monthly or longer intervals. While shorter-acting hydrophilic drugs can be made into nanocarrier-encased prodrugs, the nanocarrier encasement must be boosted to establish long-acting ...
We used the electron microprobe to study matrix in the ungrouped type 3.0 carbonaceous chondrite Acfer 094 using 7 · 7-point, focused-beam arrays; data points attributable to mineral clasts were discarded. The grid areas show resolvable differences in composition, but differences are less pronounced than we observed in studies of CR2 LaPaz Icefield (LAP) 02342 (Wasson and Rubin [2009]) and CO3....
The aim of this study was to determine if religiosity, involving dimensions such as ideology, intellect, experience, private and public practice, is related fear death test it has a role in predicting its dimensions, which are dying self, others. predictive values the control variables (gender, age) were also tested. data collected using Collett-Lester Fear Death Scale – Revised (CLFODS-R; Lest...
During studies to extend the half-life of crystalline nanoformulated antiretroviral therapy (nanoART) the mixed lineage kinase-3 inhibitor URMC-099, developed as an adjunctive neuroprotective agent was shown to facilitate antiviral responses. Long-acting ritonavir-boosted atazanavir (nanoATV/r) nanoformulations co-administered with URMC-099 reduced viral load and the numbers of HIV-1 infected C...
هدف از پژوهش حاضر برآورد درصد چربی بدن از طریق محیط بخش های مختلف بدن با استفاده از چگالی سنجی زیر آب به عنوان روش معیار وارائه معادلات مربوط به آن است. 158 نفر از دانشجویان پسر دانشگاه اصفهان( با میانگین سن 6/21 سال؛ قد 174 سانتیمتر؛ وزن 04/69 کیلوگرم؛ درصد چربی بدن 61/15؛ شاخص توده بدن 59/22 کیلوگرم بر متر مربع) که به صورت تصادفی انتخاب شده و فرم رضایت نامه و پرسشنامه سوابق پزشکی-ورزشی را تکم...
Chemopreventive agents in colorectal cancer possess either antiproliferative or anti-inflammatory actions. Nonsteroidal anti-inflammatory drugs (NSAID) and cyclooxygenase-2 inhibitors have shown promise, but are compromised by side effects. Nitric oxide donor NSAIDs are organic nitrates conjugated via a labile linker to an NSAID, originally designed for use in pain relief, that have shown effic...
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