The proximal nephron reabsorbs 60% to 70% of the fluid and sodium and most of the filtered bicarbonate via Na/H exchanger 3. Enhanced proximal nephron transport is implicated in hypertension. Our findings show that a fructose-enriched diet causes salt sensitivity. We hypothesized that fructose stimulates luminal Na/H exchange activity and sensitizes the proximal tubule to angiotensin II. Na/H e...

Abstract Reactive synthesis is an automated procedure to obtain a correct-by-construction reactive system from its temporal logic specification. GR(1) expressive assume-guarantee fragment of LTL that enables efficient and has been recently used in different contexts application domains. A common form providing system's requirements through use cases, which are existential nature. However, GR(1)...

Let F be a field and Gr(i, F ) be the Grassmannian of idimensional linear subspaces of F . A map f : Gr(i, F ) −→ Gr(j, F ) is called nesting if l ⊂ f(l) for every l ∈ Gr(i, F ). Glover, Homer and Stong showed that there are no continuous nesting maps Gr(i, C) −→ Gr(j, C) except for a few obvious ones. We prove a similar result for algebraic nesting maps Gr(i, F ) −→ Gr(j, F ), where F is an al...

Lactobacillus delbrueckii TU-1, which apparently takes intact inulin into its cells and then degrades it intracellularly, was co-cultured in vitro with L. paracasei KTN-5, an extracellular inulin degrader; or L. plantarum 22A-3, a strain that is able to utilize fructose but not inulin; or both in order to prequalify inulin as a prebiotic agent in vivo. When L. delbrueckii TU-1 was co-cultured w...

Rats fed a high-fructose diet represent an animal model for insulin resistance and hypertension. We recently showed that a high-fructose diet containing vegetable oil but a normal sodium/potassium ratio induced mild insulin resistance with decreased insulin receptor substrate-1 tyrosine phosphorylation in the liver and muscle of normal rats. In the present study, we examined the mean blood pres...

A mutant of Escherichia coli K-12 was examined which has growth medium-dependent lysyl-transfer ribonucleic acid (tRNA) ligase activity. In minimal medium or 0.5% yeast extract, the activity of the enzyme in the mutant strain was 5 to 10% of wild type. However, when the mutant was grown in a highly enriched medium, such as AC broth (Difco), the activity of the mutant ligase increased 10- to 20-...

PURPOSE Chronic renal failure (CRF) patients present with signs of immunodeficiency, such as increased incidence of infections. Cell adhesion molecules, determining leukocyte migration, may be responsible for the impaired immune response. The aim of the study was to measure soluble (s) vascular cell adhesion molecule-1 (VCAM-1), intercellular cell adhesion molecule-1 (ICAM-1), P-selectin and L-...

Gustatory receptors (Grs) expressed in insect taste neurons signal the presence of carbohydrates, sugar alcohols, CO2, bitter compounds and oviposition stimulants. The honeybee (Apis mellifera) has one of the smallest Gr gene sets (12 Gr genes) of any insect whose genome has been sequenced. Honeybees live in eusocial colonies with a division of labour and perform age-dependent behavioural tasks...

Results NCT01693562: As of May 2014, NSCLC cohort included 155 patients (pts) (median age 65 years [3385], PS 0/1/unknown [25%/73%/2%], median 3 [0-7] prior treatments). Median follow-up: 6 weeks (range 067). Treatment-related adverse events (TRAEs): 29% (Grade [Gr] ≥3: 3%); none led to treatment discontinuation. Most frequent TRAEs: fatigue (7%), nausea (5%), and vomiting (5%). No treatment-re...