Circulating murine monocytes comprise two largely exclusive subpopulations that are responsible for seeding normal tissues (Gr-1-/CCR2-/CX3CR1high) or responding to sites of inflammation (Gr-1+/CCR2+/CX3CR1lo). Gr-1+ monocytes are recruited to the site of infection during the early stages of immune response to the intracellular pathogen Toxoplasma gondii. A murine model of toxoplasmosis was thu...

PURPOSE Chronic renal failure (CRF) patients present with signs of immunodeficiency, such as increased incidence of infections. Cell adhesion molecules, determining leukocyte migration, may be responsible for the impaired immune response. The aim of the study was to measure soluble (s) vascular cell adhesion molecule-1 (VCAM-1), intercellular cell adhesion molecule-1 (ICAM-1), P-selectin and L-...

The glucocorticoid receptor (GR) is a ligand-regulated transcription factor that controls the expression of extensive gene networks, driving both up- and down-regulation. GR utilizes multiple DNA-binding-dependent and -independent mechanisms to achieve context-specific transcriptional outcomes. The DNA-binding-independent mechanism involves tethering of GR to the pro-inflammatory transcription ...

Results NCT01693562: As of May 2014, NSCLC cohort included 155 patients (pts) (median age 65 years [3385], PS 0/1/unknown [25%/73%/2%], median 3 [0-7] prior treatments). Median follow-up: 6 weeks (range 067). Treatment-related adverse events (TRAEs): 29% (Grade [Gr] ≥3: 3%); none led to treatment discontinuation. Most frequent TRAEs: fatigue (7%), nausea (5%), and vomiting (5%). No treatment-re...

We introduce the h-deformation of the algebra of functions on the grass-mann supergroup Gr(1|1) via a contraction of Gr q (1|1).

Graphene (Gr)/metal oxide nanocomposites, as advanced electrode materials, have drawn significant attention in supercapacitors due to their two components' synergistic cooperation, which compensates each other's drawbacks and hence perform better than individual components. In this study, graphene/metal Gr/NiO Gr/Co3O4 binaries were separately synthesized by a co-precipitation method NiO or Co3...

Proinflammatory cytokines have been shown to influence the expression and function of the glucocorticoid receptor (GR). Specifically, several studies have found that cytokines induce a decrease in GR function, as evidenced by reduced sensitivity to glucocorticoid effects on functional end points. To investigate the potential mechanism(s) involved, we examined the impact of the proinflammatory c...

CONDITIONAL DISCRIMINATIVE FUNCTIONS OF MEANINGFUL STIMULI AND ENHANCED EQUIVALENCE CLASS FORMATION by Roxana I. Nedelcu Adviser: Dr. Lanny Fields, Ph.D. Two experiments explored how the formation of two 3-node, 5member equivalence classes by college students was influenced by the prior acquisition of conditional discriminative functions by one of the abstract stimuli, designated as C, in the c...

Vascularization is an important factor that affects diabetic wound healing. There is increasing evidence that myeloid cell lineages play a role in neovascularization. In this study, the efficiency of Gr-1+CD11b+ myeloid cells to home to the site of injury and enhance diabetic wound healing by neoangiogenesis after intravenous administration was investigated. Gr-1+CD11b+ myeloid cells were injec...