The skin tumor-promoting ability of 1,8-dihydroxy-3-methyl-9-anthrone (chrysarobin) was compared with that of 12-O-tetradecanoylphorbol-13-acetate (TPA) and 1,8-dihydroxy-9-anthrone (anthralin) in SENCAR mice. Although dose-response comparisons indicated that chrysarobin was several orders of magnitude less potent than TPA for promoting papilloma formation, this anthrone was 1.5 to 2 times more...

The involvement of Ca2+ in the mechanism of the purgative action of rhein anthrone was studied. Among individual or combination pretreatments with calcium channel blockers, calmodulin antagonists and prostaglandin biosynthesis inhibitors, the combination of indomethacin and nifedipine completely blocked the diarrhoea induced by rhein anthrone and also inhibited its effects on colonic fluid and ...

Condensation and cyclization of 5-hydroxy- 1,2,4- thiadiazol-2-yl hydrazine 1 with pyruvic acid, phenacyl bromide, propargyl bromide and ally1 bromide afforded compounds 2,5,7 3, 4 ,6 and 8 respectively, Reaction of 1 with epichforohydrine afforded 4-hydroxy-N-[5-hydroxy- 1 ,3,4-thiadiazoly1] pyrazolidine 9

A new bio-based dimethacrylate (EMHO) consisting of three isomers, that is (ethane-1,2-diyl-bis(9-methacryloyloxy-10-hydroxy octadecanoate) [EMHO-i1], ethane-1,2-diyl-9-hydroxy-10-methacryloyloxy-9′-methacryloyloxy-10′-hydroxy octadecanoate [EMHO-i2], and ethane-1,2-diyl-bis(9-hydroxy-10-methacryloyloxy [EMHO-i3]), was made by a three-step reaction starting from esterification oleic acid with e...

The triptycene scaffold has been ring-opened by using an acidic retro-Friedel-Crafts-type reaction to give its corresponding anthrone product. 9-Hydroxytriptycenes and unsubstituted were treatment with TfOH. electron-donating group on the arene moiety allows proceed in presence of weaker acids. Additionally, applied toward synthesis tetracene. More information can be found Research Article T. I...

The characteristics of the skin tumor promotion response with anthrone derivatives has been further examined in SENCAR mice. Chrysarobin (1,8-dihydroxy-3-methyl-9-anthrone) was an effective skin tumor promoter when applied twice weekly with dose-dependent increases in both papillomas and squamous cell carcinomas between 25 and 100 nmol/mouse. A similar dose-response relationship for papilloma a...

Methods for the quantitative determination of steroids have been developed, based on their specific chemical or physicochemical properties. The Zimmermann reaction (1) and the Kober reaction (2) have been found useful in the quantitative determination of certain individual steroids occurring in urine. Modifications of these reactions have been reported by Callow et al. (3), Holtorff and Koch (4...

the synthesis of 1,5-dihydroxy-9,10-anthraquinone (17); (1,5-dha) was accomplished during, attempts towards the synthesis one of its derivatives called anthralin (1,8-dihydroxy-9-anthrone) which is known as an antipsoriasis drug since 1916 [1]. this work is a new reigiospecilic preparation of 1,5-dha based on friedel-crafts reaction starting from 1,4-dimethoxybenzene. this synthetic route, in a...