Recombinant vaccinia viruses (rVV) have been extensively used as vaccines, but there is little information about the total magnitude of the VV-specific T-cell response and how this compares to the immune response to the foreign gene(s) expressed by the rVV. To address this issue, we quantitated the T-cell responses to both the viral vector and the insert following the infection of mice with VV ...

We validated a canopy backscatter model for loblolly pine forest stands at the Duke Forest, North Carolina, by comparing the observed and modelled SAR backscatter from the stands. Given the SAR backscatter data calibration uncertainty, the model made good predictions of C-H H, C-HV, L-HH, L·HV, L-VV, P-HH, and P-HVbackscatter for most of 25 stands studied. The model overestimated C-VV backscatt...

Despite a therapeutic option for severe acute respiratory distress syndrome (ARDS), the survival benefit of venovenous extracorporeal membrane oxygenation (VV-ECMO) is still controversial in adults. This study was aimed at investigating the prognostic factors for ECMO-treated ARDS in adult patients.From 2012 to 2015, 49 patients (median age: 57 years) received VV-ECMO in our institution and wer...

Several species of marine tunicates store oxygen-sensitive VIII in blood cells. A sensitive colorimetric VIII assay was used to survey the leading candidates for the native reducing agent of vanadate in tunicates (i.e., An-type tunichromes, glutathione, NADPH, and H2S) in reactions with VV or VIV ions under anaerobic, aqueous conditions at acidic or neutral pH. Except for the case of An-1 and V...

Studies of interferon (IFN)-treated virus-infected animal cells have revealed the 2-5A system (2-5A synthetase/RNase L enzymes) as being responsible for virus inhibition only in the case of picornaviridae. To investigate whether those IFN-induced enzymes could be responsible for inhibition of poxvirus replication, we have generated recombinant vaccinia viruses (VV) containing the corresponding ...

We compared the output of the Santa Barbara microwave canopy backscatter model to polarimetric synthetic aperture radar ( S A R ) data for three ponderosa pine stands (ST2, ST-11, and SP-2) with discontinuous tree canopies near Mt. Shasta, California, at P-band (0.68-m wavelength), L-band (0.235m wavelength), and C-band (0.056-m wavelength). Given the SAR data calibration uncertainty, the model...

The attachment (G) protein of respiratory syncytial virus (RSV) is synthesized as two mature forms: a membrane-anchored form and a smaller secreted form. BALB/c mice scarified with vaccinia virus (VV) expressing the secreted form develop a greater pulmonary eosinophilic influx following RSV challenge than do mice scarified with VV expressing the membrane-anchored form. To determine if a soluble...

PURPOSE To present and validate a new method for 4D flow quantification of vortex-ring mixing during early, rapid filling of the left ventricle (LV) as a potential index of diastolic dysfunction and heart failure. MATERIALS AND METHODS 4D flow mixing measurements were validated using planar laser-induced fluorescence (PLIF) in a phantom setup. Controls (n = 23) and heart failure patients (n =...

Snow water equivalence, which is the product of snow density and depth, is the most important parameter in snow hydrology. This paper demonstrates the algorithms for estimating dry snow density, depth, grain size, underground dielectric constant and surface RMS height using multi-frequency and –polarization SAR (SIR-C/X-SAR) measurements. The algorithms were developed based on the numerically s...

AIMS Left ventricular (LV) lead placement to the most delayed segment offers the greatest potential benefit to cardiac resynchronization therapy (CRT). We assessed the impact of interventricular (VV) optimization on acute changes in cardiac output (CO) in patients with and without LV pacing of the most delayed segment. METHODS AND RESULTS In 124 patients, the most delayed segment was defined ...