TLE 1 is the human homologue belonging to a family of four genes and located on chromosome 9q21. It consists 19 exons. Although it does not bind directly DNA, acts as repressor several signalling pathways via transcription factors. TLE1 protein has physiological roles in embryogenesis, haematopoiesis, general differentiation, both neuronal eye development. Much attention was focused its express...

Software Conceptual Integrity has been considered a cardinal concern for design and development of software systems. But, except for verbal descriptions of desiderata, there were no formal tools to guarantee that conceptual integrity is attained. This paper proposes an axiomatic algebraic approach, based upon the assumption that the software system in each level of the system hierarchy is repre...