Özet Amaç: Bu çalışmada deneysel Diabetes Mellitus’un dermal doku üzerinde oluşturduğu hasara karşı propolisin muhtemel olumlu etkilerini histopatolojik parametreler ile araştırmaktır. Materyal ve Metod: Çalışmamızda 24 adet 10-12 haftalık Wistar Albino türü erkek sıçanlar Kontrol, Propolis 100mg, DM DM+Propolis (100mg) olarak rastgele 4 gruba ayrıldı. 0.1 Molar (Ph: 4,5) sitrat tamponunda çözü...

Background: Non Steroidal Anti Inflammatory Drugs (NSAIDS) are used to treat a variety of conditions associated with pain and inflammation. Analysis price variation among different brands NSAIDS provides guide for cost - effective prescribing helps reduce the financial burden on patient improves compliance. Aim: To analyze various single NSAID’s formulations available in Indian market. Material...

OBJECTIVES The authors evaluated the pharmacokinetics and tolerability of indinavir/lopinavir/ritonavir in a protease inhibitor only combination. METHODS Plasma drug levels of patients taking indinavir/lopinavir/ritonavir 800/400/100mg twice daily (n = 24, group 1) were compared to patients taking either lopinavir/ritonavir 400/100mg (n = 35, group2) or indinavir/ritonavir 800/100mg (n = 33, ...

Introduction: Nimesulide is a potent anti-inflammatorywith rapid and long-lasting effects, but also with high riskof hepatotoxicity. Objective: This work aimed to preventnimesulide-induced hepatotoxicity through the associationof nimesulide hepatoprotective agent. Materials andMethods: First, we tested three agents:N-acetylcysteine, L-carnitine, Gingko biloba extract inan in vitro hepatic cell ...

Diphenyl diselenide ([PhSe]2)is an organoselenium compound that has interesting pharmacological properties, including antioxidant, glutathione peroxidase-mimetic, and neuroprotective effects. The objective of the present study was to investigate the possible modulatory effect of (PhSe)2 in 17th-generation Carioca high-and low-conditioned freezing (CHF and CLF) rats, an animal model of generaliz...

Purpose: The seeds of Swietenia macrophylla are used in traditional medicine for the treatment of diarrhoea. Thus the petroleum ether extract of Swietenia macrophylla (Meliaceae) seeds was investigated for its anti-diarrhoeal property in Wister albino rats to substantiate folklore claim. Methods: Petroleum ether extract of the seeds of this plant, at graded doses (25, 50 & 100mg/kg body weight)...