Objective: To evaluate the frequency of PPD allergic contact dermatitis in hair dye users Faisalabad district. Study Design: Cross Sectional study. Place and Duration Study: Dermatology Outpatient Department District Headquarter Hospital, from 01-07-2018 to 31-12-2018. Methodology: A cross sectional study was carried out 135 patients were included. Male female included this with age between Res...

Stevenson, Dobriner, and Rhoads (5) reported that p-dimethylaminoazobenzene when fed to rats is decomposed and metabolized to several simpler compounds. One of these split products, N,N-dimethylp-phenylenediamine, has been found by us ( i ) to be toxic to the glandular epithelium of the rat liver at concentrations of o.oooI M, while equivalent effects on the ductal epithelium were produced only...

The tetramethyl-p-phenylenediamine oxidase reaction commonly used in the Kovacs oxidase test was quantitatively estimated for various Neisseria species employing standardized resting cell suspensions. This genus of microorganisms exhibited very high tetramethyl-p-phenylenediamine oxidase rates comparable to that of Azotobacter and Pseudomonas, and this reaction was found to be a valid measureme...

Four selected azo dyes (acid orange 6, acid orange 7, methyl orange and methyl red) were completely decolourised in the presence of anaerobic granular sludge, while only methyl red was degraded in aerobic conditions using a conventional activated sludge. Additional experiments with culture broth devoid of cells showed that anaerobic decolourisation of azo dyes was performed by extracellular red...

Histogranin (HN)-like nonpeptides were designed and synthesized using benzimidazole (compound 1) and o-phenylenediamine (compounds 2-7) as scaffolds for the attachment of phenolic hydroxyl and basic guanidino pharmacophoric elements present in HN. The benzimidazole derivative N-5-guanidinopentanamide-(2R)-yl-2-(p-hydroxybenzyl)-5-carboxybenzimidazole (1) and the o-phenylenediamine derivative N-...

The study reports some preliminary investigations on the template free synthesis of a scantly investigated polyaniline (PANI) derivative-Phenylenediamine (PDA) by template free method in the presence of Oxalic acid (OA) (dopant), using Ammonium Persulfate as oxidant. Polymerization of Phenylenediamine (PDA) was confirmed by the FT-IR as well as UV–visible studies. The morphology of Phenylenedia...

Investigations on the transfer of the ligand, imidazole (HIm), between two covalently linked redox centres--zinc porphyrin and phenylenediamine (PD)--and the influence of the length of the linker are reported. Since the binding affinity of the ligand with zinc porphyrin is different from that of the ligand with the phenylenediamine moiety, the transfer of the ligand could be electrochemically c...

The Cosmetic Ingredient Review Expert Panel (CIR Panel) reviewed the safety of hydroxypropyl bis(N-Hydroxyethyl-p-Phenylenediamine) HCl, which functions as an oxidative hair dye ingredient. The Panel considered relevant animal and human data provided in this safety assessment and concluded that hydroxypropyl bis(N-hydroxyethyl-p-phenylenediamine) HCl is safe for use in oxidative hair dye formul...

The carcinogenicity of 23 phenylenediamines and related compounds was reviewed. An extensive analysis of the methods used indicated that the bioassays were conducted well. The data suggest that the carcinogenicity of 4-substituted 1,3-phenylenediamines is reduced substantially or eliminated completely by oxidation of one or both amine groups or by N-substitution. Oxidation of a methyl substitue...