Pedro Alberto , Saurya Das , and Elias C. Vagenas 3‡ Departamento de F́ısica and Centro de F́ısica Computacional, Universidade de Coimbra, P-3004-516 Coimbra, Portugal Theoretical Physics Group, Dept of Physics and Astronomy, University of Lethbridge, 4401 University Drive, Lethbridge, Alberta, Canada T1K 3M4 and Research Center for Astronomy and Applied Mathematics, Academy of Athens, Soranou Ef...

BACKGROUND Whether T1-mapping cardiovascular magnetic resonance (CMR) can accurately quantify the area-at-risk (AAR) as delineated by T2 mapping and assess myocardial salvage at 3T in reperfused ST-segment elevation myocardial infarction (STEMI) patients is not known and was investigated in this study. METHODS 18 STEMI patients underwent CMR at 3T (Siemens Bio-graph mMR) at a median of 5 (4-6...

OBJECTIVES To assess the long-term sexual potency and attrition in sexual function after iodine-125 ((125)I) seed radiotherapy and the effect of sildenafil on radiation-induced erectile dysfunction (ED). METHODS This prospective study consisted of 86 sexually active patients (mean age 63.5 +/- 7.7 years) who underwent (125)I seed implantation from 1997 to 1999 to treat low-volume prostate can...

A procedure was developed for the immunoprecipitation of glycosylated and nonglycosylated forms of the insulin receptor and its precursors without prior purification using lectins. 3T3-L1 adipocytes were labeled with [35S]methionine after which 35S-labeled receptor polypeptides were specifically immunoprecipitated and characterized by sodium dodecyl sulfatepolyacrylamide gel electrophoresis. Th...

The therapeutic efficacy of imatinib mesylate (Gleevec) is based on its specific inhibition of the BCR-ABL oncogene protein, a widely expressed tyrosine kinase in chronic myelogenous leukemia (CML) cells. The goal of this study was to evaluate glucose metabolism in BCR-ABL-positive cells that are sensitive to imatinib exposure. Two human BCR-ABL-positive cell lines (CML-T1 and K562) and one BCR...

In the present study, we have established a stable transformation protocol via Agrobacterium tumafacines for the pharmaceutically important Withania somnifera. Six day-old nodal explants were used for 3 day co-cultivation with Agrobacterium tumefaciens strain LBA4404 harbouring the vector pCAMIBA2301. Among the different injury treatments, sonication, vacuum infiltration and their combination t...

Background Identifying depressive subtypes is an important tool in reducing heterogeneity of Major Depressive Disorder. However, few studies have examined the stability of putative subtypes of depression over time. Methods The sample included 488 persons from the Netherlands Study of Depression and Anxiety who had Major Depressive Disorder at both baseline and at the 2-year follow-up assessment...

Background and purpose — Several surgical approaches are used in primary total hip arthroplasty (THA). In this randomized controlled trial we compared gait, risk of fall, self-reported clinical measurements between subjects after direct superior approach (DSA) versus posterolateral (PL) for THA.Patients methods Participants with DSA (n = 22; age 74 [SD 8.9]) PL 23; 72 [7.7]) underwent gait anal...

We have studied the neuromuscular effects of mivacurium and changes in heart rate and arterial pressure in 40 elderly (aged 70 yr) and 20 young adult (aged 18-40 yr) patients anaesthetized with thiopentone, fentanyl, nitrous oxide in oxygen and halothane. Neuromuscular block was monitored by train-of-four (TOF) stimulation of the ulnar nerve and recording of the force of contraction of the addu...