Tumor budding has been defined as an isolated single cancer cell or a cluster composed of fewer than five cancer cells scattered in the stroma. It is a strong predictor for lymph node metastasis in T1 colorectal cancer. We introduced this concept to T1 non-muscle invasive bladder cancer and evaluated whether tumor budding could have a prognostic impact on the clinical outcome. We identified 121...

Budding yeast, which undergoes polarized growth during budding and mating, has been a useful model system to study cell polarization. Bud sites are selected differently in haploid and diploid yeast cells: haploid cells bud in an axial manner, while diploid cells bud in a bipolar manner. While previous studies have been focused on the molecular details of the bud site selection and polarity esta...

The main objective of this study was to determine the effects of vermicompost and amino acids on the qualitative and quantitative yield of chamomile. The experiment was conducted during the growing season of 2010 at the Alborz Medical Research Center. The Treatment groups consisted of vermicompost (0, 5, 10, 15 and 20 tons/ha) and the sprays of amino acids (budding stag, flowering stage, and bu...

The main objective of this study was to determine the effects of vermicompost and amino acids on the qualitative and quantitative yield of chamomile. The experiment was conducted during the growing season of 2010 at the Alborz Medical Research Center. The Treatment groups consisted of vermicompost (0, 5, 10, 15 and 20 tons/ha) and the sprays of amino acids (budding stag, flowering stage, and bu...

damage caused by water shortages leads to physiological and biochemical changes in metabolism of plants and make them predispose to attack by pests and diseases and reduce the quality of the crops. in order to evaluate the effect of supplemental irrigation on safflower fly (a. helianthi) population of safflower cultivars, an experiment conducted as a split plot based on randomized complete bloc...

Tumour budding in colorectal cancer is an important prognostic factor. A recent consensus conference elaborated recommendations and key issues for future studies, among those the use of pan-cytokeratin stains, especially in stage II patients. We report the first prospective diagnostic experience using pan-cytokeratin for tumour budding assessment. Moreover, we evaluate tumour budding using pan-...

Damage caused by water shortages leads to physiological and biochemical changes in metabolism of plants and make them predispose to attack by pests and diseases and reduce the quality of the crops. In order to evaluate the effect of supplemental irrigation on safflower fly (A. helianthi) population of safflower cultivars, an experiment conducted as a split plot based on randomized complete bloc...

The N terminus of the matrix (M) protein of vesicular stomatitis virus (VSV) and of other rhabdoviruses contains a highly conserved PPPY sequence (or PY motif) similar to the late (L) domains in the Gag proteins of some retroviruses. These L domains in retroviral Gag proteins are required for efficient release of virus particles. In this report, we show that mutations in the PPPY sequence of th...

Background/Aim. The histological phenomenon of tumor budding is being recognized as an important determinant disease progression and poor prognosis in various types carcinoma. We aimed to evaluate the clinicopathological significance adenocarcinoma lung. Methods. study included 114 patients operatively treated for lung a one-year period. Microscopic analysis routine slides was performed establi...