Introduction: Radioiodine (131I) is an effective and inexpensive alternative to surgery in the treatment of thyroid hyperfunction. The debate today concerns the maximum and minimum ablative doses, and factors leading to hypothyroidism. Patients & Method: 1035 hyperthyroid patients treated with weight-adjusted ablative doses of 131I were retrospectively assessed for ...

PURPOSE A disadvantage of conventionally radioiodinated monoclonal antibodies (mAb) for cancer therapy is the short retention time of the radionuclide within target cells. To address this issue, we recently developed a method in which radioiodine is introduced onto antibodies using an adduct consisting of a nonmetabolizable peptide attached to the aminopolycarboxylate diethylenetriaminepentaace...

OBJECTIVE Neuroblastoma is the third most common malignancy of childhood. 131I-MIBG scintigraphy must be performed in patients with neuroblastoma at the time of staging. The aim of this study is to identify the role of 131I-MIBG scintigraphy in neuroblastoma patients in correlation with other diagnostic modalities for staging of the disease. METHODS Twenty six patients provisionally diagnosed...

Treating breast cancer brain metastases (BCBMs) is challenging. Na+/I- symporter (NIS) expression in BCBMs would permit their selective targeting with radioiodide (131I-). We show impressive enhancement of tumor response by combining131I- with gemcitabine (GEM), a cytotoxic radiosensitizer. Nude mice mammary fat-pad (MFP) tumors and BCBMs were generated with braintropic MDA-MB-231Br cells trans...

Studying the migration and diffusion of radionuclides plays an important role in emergency decision making accident mitigation floating nuclear power plants. Based on CALPUFF model, this paper simulates spatial distribution concentration airborne 131I under conditions sailing supply LOCA (Loss-of-Coolant Accident) plant, influence four meteorological parameters, namely wind speed, cloudiness, t...

m-[l25I]iodobenzylguanidine (m-[125I]MIBG) has been suggested as an alternative to m-[131I]MIBG for the treatment of metastatic neuroblastoma to achieve a higher radiation dose in micrometastases. To compare these two radiopharmaceuticals, a mathematical model was developed in the present study that allows for the calculation of radiation dose rates within small spherical tumors for different d...

used for thyroid disease could generate a chromosomal aberration, particularly (t 9,22) (q34 q11) developing, with a long latency, CML or in this case Ph+ ALL. Although the risk of leukemia after 131I exposure cannot be considered a contraindication to 131I therapy, strict hematologic follow-up of patients submitted to 131I treatment is recommended. Retrospective analysis of 131I exposure in la...

Detection of residual tissue after thyroidectomy for papillary or follicular thyroid carcinoma may be performed using diagnostic imaging with either 123I or 131I. The former is often preferred to avoid ‘‘stunning’’—defined as a reduction in uptake of the therapeutic dose of 131I caused by some form of cell damage from the diagnostic dosage of the radionuclide. Stunning could potentially reduce ...

INTRODUCTION The aim of this study was to investigate the effects of 131I gelatin microspheres (131I-GMS) on human breast cancer cells (MCF-7) in nude mice and the biodistribution of 131I-GMSs following intratumoral injections. METHODS A total of 20 tumor-bearing mice were divided into a treatment group and control group and received intratumoral injections of 2.5 mci 131I-GMSs and nonradioac...

Iodine-131 (131I) is widely used for the treatment of thyroid-related diseases. This study aimed to investigate the expression of p53 and BTG2 genes following 131I therapy in thyroid cancer cell line SW579 and the possible underlying mechanism. SW579 human thyroid squamous carcinoma cells were cultured and treated with 131I. They were then assessed for 131I uptake, cell viability, apoptosis, ce...