not only cancer cells but also normal cells. Because these drugs are not specifically selective for cancer cells, patients suffer from adverse side effects due to the loss of healthy cells. Therefore, it is important to reduce such side effects caused by anti-cancer drugs. DNA damage induces signal transduction pathways called checkpoints, which delay cell cycle progression and permit repair of...

عاطقلا طبر ي يذ لا ة يبرهكلا ىو قلا ماظنل يكيمانيدلارارقتسلال ةضيفتسم ةيلمع ةسارد ثحبلا اذه مدقي ني ب ة لوقنملا ةرد قلا ةدا يز ى لع ك لذ ريثأ ت و ةيدوعس لا ءا برهآ ةآر ش ن م ط سولأا عا طقلا و يقرش لا نيعاطقلا ، ىوقلا مظن تاتبثم طبض للاخ نم كلذو . دقل شم ةغايص مت ةلك طبض ةروص ىف تاتبثملا هذه ةلثمأ ةلكشم . ماظنلا ءادأ نيسحتل ك لذو ةدر فنملا ماظنلا ميق ىلع نادمتعت فده يتلاد حارتقا مت دقلو . د قلو ...

1Department of Oncology, Wayne State University, Detroit, MI 48201-1379, USA 2Department of Urology, Wayne State University, Detroit, MI 48201, USA 3Department of Medicine, University of Illinois at Chicago, Chicago, IL 60607-4067, USA 4Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD 20892-7335, USA 5 Integrated Cancer Genomics Division, The Translational G...

Ed. note: Continuing comment on the role of the clinical chemist Icf. Clin. Chem. 23 1961 (1977)1. A major step in rectifying the “disastrous impact” mentioned here was the first Arnold 0. Beckman conference Icf. Clin. Chem. 23, 1379 (1977)1, the proceedings of which will be published by AACC later this year. This conference has received a good deal of praise from the participants, and was evid...

In this paper, we prove some coupled fixed point theorems for Ocompatible mappings in partially ordered generalized metric spaces under certain conditions to extend and complement the recent fixed point theorems due to Bhaskar and Lakshmikantham [Nonlinear Anal. TMA 65 (2006) 1379 1393] and Berinde [Nonlinear Anal. TMA 74 (2011) 7347-7355]. We give some examples to illustrate our results. An ap...

Gil Sánchez Muñoz, de familia noble Teruel, canónigo paborde Valencia, tío su homónimo que posteriormente será el papa Clemente VIII, embajador Gregorio XI, se encontraba en Roma momento la muerte del pontífice y controvertido cónclave salió elegido Urbano VI (abril 1378), con quien inicialmente mantuvo una muy estrecha relación. Sin embargo, ya septiembre 1379 las declaraciones ante Pedro IV, ...