Prostate cancer cells depend on androgens and the androgen receptor (AR) for survival. However, after androgen ablation therapy, tumors relapse to an androgen-refractory state. To determine whether the androgen receptor is critical for proliferation of androgen-refractory prostate cancer cells, we disrupted the activity of the androgen receptor with an antibody and an AR mRNA hammerhead ribozym...

Macrophage inhibitory cytokine 1 (MIC-1), a divergent member of the transforming growth factor-beta superfamily, is linked to the pathogenesis of cancer. To delineate possible roles for MIC-1 in prostate cancer, a number of prostate epithelial cell lines have been studied, including PZ-HPV-7, DU-145, PC-3, and LNCaP cells. Factors regulating the production of MIC-1 protein by these cells and so...

The proinflammatory protein endothelial monocyte-activating polypeptide II (EMAP-II) was first detected in supernatants of murine tumor cells by virtue of its ability to stimulate endothelial-dependent coagulation in vitro. The purified protein has pleiotropic effects on endothelial cells, monocytes, and neutrophils; however, its function in vivo is unknown, and the mechanism whereby it is rele...

The stilbenoids E-resveratrol (E-3,5,4'-trihydroxystilbene, 1), E-3,5,4'-trimethoxystilbene (2), E-3,4,4'-trimethoxystilbene (3) and E-3,4'-dimethoxy-5-hydroxystilbene (4) were converted by photoisomerization to their corresponding Z-isomers 5-8. Compounds 1-8 were subjected to antiproliferative activity bioassays towards a set of four different human cancer cell lines, namely DU-145 (androgen ...

Adrenomedullin (AM) is a multifunctional peptide expressed in the normal and malignant prostate, and in prostate cancer cells. To elucidate the potential role of AM in prostate cancer, we have transfected the human AM gene into PC-3, DU 145, and LNCaP prostate cancer cells. Northern blot, Western blot, and radioimmunoassay techniques confirmed an increase in the synthesis and secretion of the 6...

1 لوئسم هدنسيون : شناد دشرا يسانشراك هتخومآ هدكشناد ،شزرو يژولويزيف تيبرت ،يشزرو مولع و يندب هاگشناد ناهفصا يكينورتكلا تسپ : [email protected] 2 رايداتسا تيبرت هورگ يندب و مولع دا هدكشناد ،يشزرو ،تايب هاگشناد ناتسدرك 3 شناد هتخومآ سانشراك ي دشرا هدكشناد ،شزرو يژولويزيف تيبرت ،يشزرو مولع و يندب هاگشناد نلايگ 4 شناد دشرا يسانشراك هتخومآ هدكشناد ،شزرو يژولويزي...

هتفای اه : یم ناشن جیاتن اب هورگ هک دنهد PRAL هلیزوکیلگ نیبولگومه نییاپ %] 5 / 0 ± 7 / 5 لباقم رد % 5 / 0 ± 8 / 7 و 01 / 0 p= [ لیاسا يرت لورسیلگ ] mg/dl 3 / 2 ± 9 / 246 لباقم رد 3 / 2 ± 4 / 257 و 006 / 0 p= [ یلوتسیس راشف ، ] mmHg 7 / 0 ± 6 / 103 لباقم رد mmHg 7 / 0 ± 1 / 106 و 03 / 0 p= [ هورگ هب تبسن يرتمک ياتشان نوخ دنق و نینیتارک ، PRAL دنتشاد رتلااب . Pro:k میقتسم طابترا ه...

* لوئسم هدنسيون : تسراميب ،رفظ ،سردم نا رغصا يلع ) ع ( نفلت : 9 44503395 email: [email protected] فده و هنيمز : هچب رد يناجيه و يراتفر تلاكشم هسياقم شهوژپ نيا زا فده اب ردام يتسرپرس تحت دلاو كت ياه هداوناخ ينيمخ ماما دادما هتيمك رد دلاو ود ياه ) هر ( تسا نارهت . لثم يمئلاع يراتفر تلاكشم زا روظنم زا روظنم و تسا يعامتجا تلاكشم و يراكهزب ،يرگشاخرپ و بارطضا ،يگدرسفا لثم يمئلاع يناجيه ...

Uteroglobin (UG) is a potent immunomodulatory and antiinflammatory secretory protein with high levels detected in human prostate tissue. We used three human prostate cancer cell lines (DU-145, PC3-M, and LNCaP) to test the hypothesis that UG may modulate invasiveness of prostatic carcinoma cells in the Boyden chamber assay for invasion through a reconstituted basement membrane preparation. Fibr...

کچ هدي پ شي مز هني فده و : شزومآ لاب يني شخب ساسا ي شزومآ مهم و راتسرپ ي تسا . و هنوگ ره دوج لکشم ي شزومآ رد لاب يني ، آراک يي هدزاب و ا ني شزومآ زا شخب راچد ار لکشم م ي دنک . فده اب رضاح شهوژپ سررب ي لماوع سرتسا از ي شزومآ لاب يني رد وجشناد ناي راتسرپ ي هدکشناد راتسرپ ي و يامام ي ماـجنا داـبآ مرـخ تسا هتفرگ . شور و داوم راک : رضاح هعلاطم کي هعلاطم صوت يفي عطقم ي تسا . د...