background: with the prevalence of 6-10%, polycystic ovarian syndrome (pcos) is considered the most common endocrinological disorder affecting women in their reproductive age. it has been suggested that genetic factors participate in the development of pcos. follicular development has been considered as one of the impaired processes in pcos. bone morphogenetic protein-15 (bmp-15) gene is a cand...

Objective(s): We aimed to examine association of gene expression of MOR1 and GluN1 at mRNA level in the lumbosacral cord and midbrain with morphine tolerance in male Wistar rats. Materials and Methods: Analgesic effects of morphine administrated intraperitoneally at doses of 0.1, 1, 5 and 10 mg/kg were examined using a hot plate test in rats with and without a history of 15 days morphine (10 mg...

Circulating lipoproteins may offer interesting properties as therapeutic carriers for cytokines and hormones, in terms of both stability and bio-distribution. The fusion of apolipoprotein A-I with interleukin-15 (IL-15) targets the latter to high-density lipoproteins (HDLs). The bioactivity of this chimera can be further enhanced by creating triple fusions with IL-15 receptor α domain involved ...