BACKGROUND Progestins as respiratory stimulants in chronic obstructive pulmonary disease (COPD) have been investigated in males and during wakefulness. However, sleep and gender may influence therapeutic responses. We investigated the effects of a 2-week medroxyprogesterone acetate (MPA) therapy on sleep and nocturnal breathing in postmenopausal women. METHODS A single-blind placebo-controlle...

The aim of this study was to evaluate the frequency and clinical associations of HLA-DR alleles in Brazilian Caucasian patients with polyarteritis nodosa (PAN) or microscopic polyangiitis (MPA). We evaluated 29 Caucasian patients with vasculitis classified as PAN or MPA according to the American College of Rheumatology (ACR) 1990 Criteria, Chapel Hill Consensus Conference (CHCC) nomenclature fo...

BACKGROUND AND OBJECTIVES Adequate early mycophenolic acid (MPA) exposure is an important determinant for effective rejection prophylaxis. This pharmacokinetic study investigated whether an intensified dosing regimen of enteric-coated mycophenolate sodium (EC-MPS) could achieve higher mycophenolic acid (MPA) exposure early after transplantation versus a standard dosing regimen. DESIGN, SETTIN...

abstract introduction: the mineral content of dentin increases with age and its primary structure is altered. these changes may have unknown effects on efficiency of adhesive systems. the aim of this study was to find the effect of aging on dentin bonding agents. methods and materials: fourty eight extracted human premolars were divided into 2 groups under 15 years old & 2 groups over 45 years ...

OBJECTIVE Combined hormone therapy (HT) containing estrogen and progestin (medroxyprogesterone acetate [MPA]) leads to increased risk of breast cancer in postmenopausal women, compared with HT regimens containing estrogen alone or placebo. We previously reported that in animal models, progestins can accelerate the development of mammary tumors by increasing vascular endothelial growth factor (V...

In this paper the effect of hardener on mechanical properties of carbon reinforced phenolic resin composites is investigated. Carbon fibre is one of the most useful reinforcement materials in composites, its major use being the manufacture of components in the aerospace, automotive, and leisure industries. In this study, carbon fibres are hot pressed with phenolic resin with various percentages...

Methods In this study we performed a microarray analysis in a distillery Saccharomyces cerevisiae strain (BT0510) submitted to sublethal pressure treatment of 50 MPa for 30 min at room temperature, followed by incubation for 5, 10 and 15 min at room pressure (0.1 MPa). The transcription of the genes involved in central carbon metabolism in response to HHP was investigated for bioinformatics tools.

BACKGROUNDS/AIMS Mycophenolate mofetil (MMF) has wide inter- and intra-individual variability of mycophenolic acid (MPA) after liver transplantation (LT). On this study, we aimed to analyse the intra-individual variability of MPA concentration in stable adult LT recipients receiving MMF monotherapy and develop a method to determine the target level in the situation of wide intra-individual vari...

Detailed analysis of the voltammetry of decamethylferrocene at micro and macrodisc electrodes has been carried out in scCO2/MeCN (15 wt%), 20 mM [NBu(n)4][BF4] and 309 K and 17.5 MPa. A passivating film needs to be removed from platinum electrodes before stable, reproducible voltammetry can be obtained. At low concentrations (0.22 mM) reversible 1e(-) behaviour is observed. Significant effects ...

The effect of single-cycle and multiple-cycle high hydrostatic pressure (HHP) treatments on the survival of three Salmonella Enteritidis strains in chicken breast fillets was investigated. The surface of fillets was inoculated with a cocktail of three Salmonella strains at approximately 10(7) colony-forming units (CFU)/g, and held at 4 degrees C for 20 hours before HHP treatments. Reduction of ...