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The phenotype of excitatory cerebral cortex neurons is specified at the progenitor level, orchestrated by various intrinsic and extrinsic factors. Here, we provide evidence for a subcortical contribution to cortical progenitor regulation by thalamic axons via ephrin A5-EphA4 interactions. Ephrin A5 is expressed by thalamic axons and represents a high-affinity ligand for EphA4 receptors detected...
We present a 16-year-old patient with Wolff-Parkinson-White syndrome admitted with syncope and aborted sudden cardiac death. Electrocardiography showed only a short PR interval without a delta wave. The QRS transition zone was on V2 in the precordial leads. Twenty-four-hour ambulatory cardiac rhythm monitoring showed an obvious delta wave only at night-time. Electrophysiologic testing was perfo...
Mendel's paper 'Versuche über Pflanzen-Hybriden' is the best known in a series of studies published in the late 18th and 19th centuries that built our understanding of the mechanism of inheritance. Mendel investigated the segregation of seven gene characters of pea (Pisum sativum), of which four have been identified. Here, we review what is known about the molecular nature of these genes, which...
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