Two new highly oxidized humulane sesquiterpenes, mitissimols D (1) and E (2) were isolated from the fruiting bodies of Lactarius mitissimus. Their structures were elucidated using extensive spectroscopic techniques including 1D and 2D NMR spectra.

PURPOSE Local inflammation at the RPE cell layer is associated with inflammatory cell migration and secretion of proinflammatory cytokines such as tumor necrosis factor (TNF)-α. TNF-α upregulates intercellular adhesion molecule (ICAM)-1 expression on the RPE, which allows lymphocyte function-associated antigen-1 (LFA-1) to bind on leukocytes that contribute to leukocyte adhesion at sites of inf...

s Fluoride 43(2)165–168 April-June 2010 Abstracts 165 165

New flea-like fossils from China provide a rare, tantalizing glimpse of bizarre insects in the Cretaceous and Jurassic. Possibly the oldest flea-like animals known, they provide a challenge to the functional morphologist to infer which animals they may have targeted.

BACKGROUND Vascular endothelial growth factor (VEGF), which affects tumor angiogenesis, is expressed as different splice variants, including the major isoforms VEGF(165) and VEGF(121), and can be cleaved by plasmin to generate VEGF(110). The amount of VEGF(121) and VEGF(110) in biological samples has not been well studied. METHODS We developed an ELISA that detects VEGF(165) and VEGF(121) equ...

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1 12 | introduction and outline introduction Working with people who experience severe psychological trauma leaves the therapist sometimes shocked about their horrifying, almost unbelievable histories and about the scars this may have caused, and at the same time intrigued by the way people were able to survive. In my daily practice, listening to details of a history of child abuse from a patie...

The natural question to ask is: Why does this odd behavior occur in the kidney stone treatment example? When comparing the treatments with the aggregated data, an assumption is implicitly being made that the decision for which treatment to use does not depend upon the size of the kidney stones. It turns out that this implicit assumption is incorrect, because open surgery was more often used for...