conclusions it appears that fenugreek seed might be effective against hyperglycemia, hyperlipidemia and insulin resistance in ovariectomized rats without impact on serum apelin. furthermore, 17-β estradiol could have similar effects along with possible inhibitory effects on serum apelin. the complicated role of apelin in menopause needs to be further explored. results serum apelin, glucose, lip...

Bone marrow stem cells (BMSCs) have the capacity to differentiate into mature cell types of multiple tissues. Thus, they represent an alternative source for organ-specific cell replacement therapy in degenerative diseases. In this study, we demonstrated that female rat BMSCs could differentiate into steroidogenic cells with the capacity for de novo synthesis of Estradiol-17 β (E2) under high gl...

The present study was conducted to characterize possible rapid effects of 17-β-estradiol on voltage-gated K(+) channels in preoptic neurons and, in particular, to identify the mechanisms by which 17-β-estradiol affects the K(+) channels. Whole-cell currents from dissociated rat preoptic neurons were studied by perforated-patch recording. 17-β-Estradiol rapidly (within seconds) and reversibly re...

Natural estrogens are present in high concentrations livestock slurries, which often applied to agricultural fields large quantities. As such, the export of slurry-derived natural from tile-drained is a potential source for estrogenic pollution surface waters. Yet despite abundance Central Europe, receiving slurries rarely studied this region. In an effort fill knowledge gap, here we Swiss expe...

Estrogens are important environmental contaminants that disrupt endocrine systems and feminize male fish. We investigated the potential for anaerobic biodegradation of the estrogens 17-alpha-ethynylestradiol (EE2) and 17-beta-estradiol (E2) in order to understand their fate in aquatic and terrestrial environments. Cultures were established using lake water and sediment under methanogenic, sulfa...

Objective: A simple high-performace liquid chromatography method was developed and validated to determine 17-β estradiol in poly (ε-caprolactone) nanocapsules.
 Methods: The chromatographic conditions were as follows: C18 GL column with a mobile phase of acetonitrile:water (92:8 v/v) at flow rate 1.5 mL/min detection 280 nm. evaluated parameters specificity, linearity, limits quantificatio...

This study was investigated the effects of dietary estradiol-17? (E2) on growth, body composition and blood indices in Acipenser stellatus. Fish (40.9 ? 1.1 g average initial weight; n = 60 per group) were fed with three different diets containing 0 (control), 25 and 50 mg kg-1 dietary estradiol contents to apparent satiation for seven months. The results suggested that growth rate were decreas...

The presence of steroid hormones in lake waters causes contamination aquatic ecosystems, which may cause endocrine alterations the organisms that inhabit them. Moreover, many these are purified and distributed to populations located around lake. Therefore, effects could be repeated humans consuming water. This study reports hormone residues inner bay Lake Titicaca drinking water city Puno (Peru...

BACKGROUND Estrogen is known to play role in temporomandibular joint (TMJ) disorders and estrogen effects can be mediated by estrogen receptor (ER) alpha present in the TMJ. Cells expressing the estrogen receptor ERalpha are present in the temporomandibular joint (TMJ) but changes in expression due to estrogen and inflammation have not been characterized. In this study, ERalpha protein content ...

We investigated the effect of high-frequency electromagnetic fields (HF-EMFs) and 17-β-estradiol on connexins (Cxs), integrins (Ints), and estrogen receptor (ER) expression, as well as on ultrastructure of trophoblast-derived HTR-8/SVneo cells. HF-EMF, 17-β-estradiol, and their combination induced an increase of Cx40 and Cx43 mRNA expression. HF-EMF decreased Int alpha1 and β 1 mRNA levels but ...