Vol. 1, No. 4 ■ May 2001 U ntil quite recently, the seizure disorders of childhood were broadly associated with generalized disruptions in brain maturation and, by association, the complete range of behavioral and intellectual deficits common in children with epilepsy. This concept of pediatric epilepsy as a cause of diffuse cognitive problems was supported by several lines of evidence as well ...

The γ subunits of heterotrimeric AMPK complexes contain the binding sites for the regulatory adenine nucleotides AMP, ADP and ATP. We addressed whether complexes containing different γ isoforms display different responses to adenine nucleotides by generating cells stably expressing FLAG-tagged versions of the γ1, γ2 or γ3 isoform. When assayed at a physiological ATP concentration (5 mM), γ1- an...

In vivo ablation of malignant B cells can be achieved using antibodies directed against the CD20 antigen. Fine specificity differences among CD20 monoclonal antibodies (mAbs) are assumed not to be a factor in determining their efficacy because evidence from antibody-blocking studies indicates limited epitope diversity with only 2 overlapping extracellular CD20 epitopes. However, in this report ...

In vivo ablation of malignant B cells can be achieved using antibodies directed against the CD20 antigen. Fine specificity differences among CD20 monoclonal antibodies (mAbs) are assumed not to be a factor in determining their efficacy because evidence from antibody-blocking studies indicates limited epitope diversity with only 2 overlapping extracellular CD20 epitopes. However, in this report ...

(i) The integral of a non-negative extended real-valued measurabele function f on R d is given by R d f (x)dx = sup g R d g(x)dx where the supremum is taken over all bounded functions 0 ≤ g ≤ f which are bounded and supported on a set of finite measure. (ii) First suppose α < −n, and define a strictly decreasing sequence x m 0. We define step functions g n as follows. Define the sets A m = B xm...